The Ultimate Human with Gary Brecka

You might think Alzheimer's starts in your 70s. Dr. David Perlmutter explains why it begins decades earlier, and how the p-tau 217 blood test flags risk long before symptoms appear. Gary Brecka and Dr. Perlmutter break down microglia, insulin resistance, pre-diabetes, APOE4, homocysteine, vitamin D, creatine and sleep, plus what the POINTER study showed about cognitive decline in metabolically compromised adults.

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Timestamps

00:00 - Intro of the Show

01:33 - Grain Brain and ultra-processed carbohydrates

03:26 - Pre-diabetes decades before any symptoms

08:03 - Type 3 diabetes and insulin in the brain

11:48 - The fasting insulin level to target

14:08 - Immunometabolism and your microglial cells

16:12 - APOE4 as predisposition, not destiny

19:25 - Inflammation from the gut, mouth and air

25:50 - Aerobic vs resistance training for the brain

30:04 - Sarcopenia, myokines and BDNF

34:44 - Mitochondria and the TSPO brain scan

40:11 - The Tanzi, Ornish and POINTER trials

46:31 - Beta-amyloid drugs and the Cochrane data

55:00 - Sleep, the glymphatic system and insulin

58:25 - Creatine dosing and the creatinine confusion

1:03:52 - Vitamin D, VDR polymorphisms and tau

1:09:35 - Fish oil, DHA and the omega-3 study

1:12:48 - Homocysteine, B complex and MTHFR

1:18:43 - Red light, RNS60 and mitochondrial transplant

1:27:11 - Isolation, cortisol and oxytocin

1:32:58 - What it means to be an ultimate human

Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions.

Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation. Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered promotional in nature.
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NAD+ became a $4.5 billion industry of IV drips, patches, nasal sprays and powders almost overnight, with clinics charging $2,000 a bag to reverse your age and cure your hangover. Some of what you have been told about NAD+ is true. Some of it is complete nonsense. Gary Brecka runs seven of the biggest NAD+ claims against the research and tells you exactly which is which.

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Watch the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST:

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Timestamps

00:00 – Intro of Show

02:05 – Every calorie passes through NAD+ to become ATP

02:15 – The enzymes that burn NAD+ for metabolism and DNA repair

02:45 – Liver tissue runs 30% lower after 60

03:15 – CD38 and chronic inflammation destroy the NAD+ pool

03:40 – Replenish, slow the drain, support recycling

03:52 – NMN and nicotinamide riboside as precursors

04:35 – Why raw NAD+ is torn apart in the gut

05:00 – Cancer history, pregnancy and who should not take it

06:35 – Sunlight, sleep and movement come first

Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions.

Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation. Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered promotional in nature.
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Wildlife biologist Forrest Galante has spent his life around animals that have constant access to food and never eat themselves into obesity or liver disease, and he argues that what humans do traces back to the one thing we have spent a century engineering out of our lives. Gary and Forrest get into why the aggressive pursuit of comfort may be what is aging you fastest.

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Watch the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST:

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Timestamps

00:00 - Intro of Show

05:09 - Hardwired for indulgence

19:24 - Nature disconnection and chronic illness

21:10 - Artificial light, screens, and filtered air

21:36 - Grounding and red blood cell clumping

23:40 - How much nature you actually need

27:50 - Seed oils reaching remote tribes

29:29 - Sedentary living and the pursuit of comfort

31:38 - Why we now simulate discomfort

32:28 - Grass-fed, pasture-raised and free-range

47:01 - Diving with the squid in chainmail

01:07:00 - Conditioned to fear the natural world

01:10:41 - What it means to be an ultimate human

Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions.

Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation. Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered promotional in nature.
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You might think your anxiety is a mindset problem. It isn't. In this episode, human biologist Gary Brecka explains why chronic stress leaves your autonomic nervous system stuck in fight-or-flight, and how elevated cortisol degrades your gut lining, suppresses your immune system, stores fat around your midsection and, according to research on chronic stress and telomeres, may accelerate how fast you age. He breaks down the vagus nerve as the physical brake line of your parasympathetic system, then walks through four free daily resets you can start today: the physiological sigh and five minutes of slow breathing before you touch your phone, 30 seconds of cold at the end of your shower, ten minutes of morning sunlight in your eyes with your feet on the ground, and two hard rules on caffeine and the last hour before bed. No pills, no supplement stack, no subscription. If you wake up exhausted, your heart races for no reason and you lie down tired and wired, this one explains why.

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Timestamps

00:00 - Introduction: Tired and wired, and what it means

01:17 - Your anxiety is not in your head

02:53 - Fight or flight versus rest and digest

04:03 - What chronic cortisol does to your gut lining

04:27 - Why your blood panel comes back normal

05:09 - The vagus nerve is your brake line

05:33 - Reset 1: Breathwork and the physiological sigh

07:09 - Reset 2: Cold exposure and your HRV

08:13 - Reset 3: Morning sunlight and cortisol rhythm

09:20 - Reset 4: Caffeine cutoff and the last hour before bed

10:32 - Pick one reset and start today

Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions.

Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation. Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered promotional in nature.
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Mold toxins show up in 90% of Dr. Richard Horowitz's chronically ill patients, and Lyme shows up in more. After 41 years and 13,000 cases, he just published the first documented reversal of an Alzheimer's blood marker using nine weeks of oral antibiotics.

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Watch the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST:

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Connect with Gary Brecka

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Timestamps

00:00 - Introduction: Alzheimer's, Lyme and inflammation

01:20 - Memory loss in a parent

06:30 - Reversing an Alzheimer's biomarker

09:00 - Mycotoxins in 90% of patients

11:00 - Why 42% over 55 face dementia

16:00 - Migratory pain and diagnosing Lyme

18:20 - Why the CDC Lyme test fails

22:28 - Why doxycycline fails for chronic Lyme

31:02 - MS and rheumatoid arthritis misdiagnosed

38:11 - Mold and heavy metal testing

43:13 - Low testosterone and Lyme

46:37 - Long COVID, adrenals and autoimmunity

50:30 - The girl on 480 milligrams of morphine

56:30 - The nine-week oral protocol

01:01:30 - Glutathione, NAC and blocking inflammation

01:15:15 - The Alzheimer's biomarkers to order

01:32:20 - What does it mean to be an Ultimate Human

Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions.

Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation. Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered promotional in nature.
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