Core Memory

The mainstream media says almost nothing about induced pluripotent stem cells (iPSCs). So, you’re lucky that we’re here to help.
These cells with a clunky name hold the promise of being able to reverse the aging process across our bodies. Put rather bluntly, your old, wine-soaked liver could become like your twenty-something, Jell-O-shot-soaked liver. Your aging neurons could fire like they once did. And your tired heart could be fresh and loving again.
Billions of dollars have been funneled toward trying to figure out how to push iPSCs into our organs safely and effectively. We have not cracked the code yet, but there are signs that scientists are getting closer.
Nabiha Saklayen, the co-founder and CEO of Cellino Bio, is an iPSC whiz and joined the podcast this week to bring us all up to speed on the technology. She covers how iPSCs work, their history and the state of iPSC treatments around the world.
Her company is trying to take iPSCs, which have largely been made by hand, and mass produce them to accelerate experimentation and hopefully therapies and to reduce costs around this fascinating technology.
The Core Memory podcast is on all major platforms and on our YouTube channel over here. If you enjoy the show, please leave a review and tell your friends.
This podcast is sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.
We run on Brex and so should you. Learn more about Brex right here.
The podcast is also made possible by E1 Ventures, which backs the most ambitious founders and start-ups.


This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe

Will Wilson paints a bleak picture for where we’re heading with code written by AIs.
He thinks the world will fill with poorly written code that no one understands and that software bugs will proliferate through critical systems. Your airplane that has gotten safer and safer with each passing decade will be running on code that no one has really checked all that well. Which would be bad.
What’s more, Wilson fears that humans will lose their software writing skills over time as AI takes on more and more tasks. We’ll become dumber as a whole. Which would also be bad.
Wilson is a mathematician turned start-up founder who built the company Antithesis in a bid to modernize software testing techniques and help humans write better code.
In this episode, we get into his life story, his fears around AI software and what he thinks we should do to make massive improvements to the code that underlies everything.
The Core Memory podcast is on all major platforms and on our YouTube channel over here. If you enjoy the show, please leave a review and tell your friends.
This podcast is sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.
We run on Brex and so should you. Learn more about Brex right here.
The podcast is also made possible by E1 Ventures, which backs the most ambitious founders and start-ups.



This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe

Anna Prouse has survived multiple assassination attempts. She’s been tapped by General David Petraeus to get work done in Iraq that U.S. troops couldn’t handle. She’s faced off against Iranian militants. Over a multi-decade career working in the Middle East, Prouse earned the rarest of titles – “Honorary Man” – because of her ability to thrive and hold positions of authority in a hyper-masculine society.
(If you can’t tell, we’re going a little off schedule with this week’s podcast. I heard about Prouse’s story from a friend and had no choice but to have her on the show.)
Born in Italy, Prouse is a former journalist who ended up in Iraq in 2003 and went to work trying to rebuild the country’s health infrastructure first for the Red Cross and then on behalf of the U.S. government. She lived in constant danger for many years and proved adept at moving between the U.S., Iraqi and Iranian powers because of her unique approach to problem-solving.
More recently, Prouse has worked in Silicon Valley, including a stint at Google where she found complaints from the workforce about the quality of the quinoa and sushi quite comical.
As if her career was not dramatic enough, Prouse also survived a brain tumor during what were meant to be her easier years.
We discuss all of this in the show, using Prouse’s best-selling memoir as a guide through her journey.
The Core Memory podcast is on all major platforms and on our YouTube channel over here. If you enjoy the show, please leave a review and tell your friends.
This podcast is sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.
We run on Brex and so should you. Learn more about Brex right here.
The podcast is also made possible by E1 Ventures, which backs the most ambitious founders and start-ups.'



This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe

Ed Boyden has spent the last twenty or so years building the technology needed to create a working simulation of living systems. Put another way – he’s been trying to turn biology into physics.
Boyden has helped develop new techniques for imaging the brain and the body, including optogenetics and expansion microscopy. He’s also known for nurturing all-star talent at his lab at MIT and he and his students have gone on to form numerous bio-tech start-ups. Overall, Boyden is regarded as one of the top scientific minds of this era.
It was a genuine honor to have Boyden on the show, and we’re sure you’ll enjoy this episode.
In this episode, filmed at Boyden’s office, we discuss his background as a child prodigy, his work and what it might actually mean to engineer something like a mind or consciousness. We also get into Boyden’s skepticism around current large language models and the state of science funding in the U.S.
The Core Memory podcast is on all major platforms and on our YouTube channel over here. If you enjoy the show, please leave a review and tell your friends.
This podcast is sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.
We run on Brex and so should you. Learn more about Brex right here.
The podcast is also made possible by E1 Ventures, which backs the most ambitious founders and start-ups.



This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe

We do not usually do venture capitalists on the Core Memory podcast. They can be a lot and like to hear themselves talk a bit too much. (Not you! The other ones – Ed.)
But, for Peter Barrett, we will always make an exception. He’s a general partner at Playground Global and is one of those people who knows an awful lot about an awful lot of things. He is one of my favorite people to listen to and gets my mind racing with tons of new ideas every time we speak.
Self-taught, Peter spent the early part of his career as a force of nature in the software industry. He was visited by the Men In Black as a teenager. He helped start Rocket Science Games, which was the hottest video game maker in town before it wasn’t. While there, Peter happened to employ a young intern named Elon Musk. . .
Later, Peter would be part of the team that created WebTV and a longtime distinguished engineer at Microsoft, working alongside Bill Gates and Steve Ballmer.
These days Peter goes deep on deep tech at Playground. As such, we talk quantum computing, the insane world of AI agents, nuclear power, data centers in space (and why they won’t work) and whether or not humans should be in total panic.
The Core Memory podcast is on all major platforms and on our YouTube channel over here. If you enjoy the show, please leave a review and tell your friends.
This podcast is sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.
We run on Brex and so should you. Learn more about Brex right here.
The podcast is also made possible by E1 Ventures, which backs the most ambitious founders and start-ups.


This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe