Core Memory

Anna Prouse has survived multiple assassination attempts. She’s been tapped by General David Petraeus to get work done in Iraq that U.S. troops couldn’t handle. She’s faced off against Iranian militants. Over a multi-decade career working in the Middle East, Prouse earned the rarest of titles – “Honorary Man” – because of her ability to thrive and hold positions of authority in a hyper-masculine society.
(If you can’t tell, we’re going a little off schedule with this week’s podcast. I heard about Prouse’s story from a friend and had no choice but to have her on the show.)
Born in Italy, Prouse is a former journalist who ended up in Iraq in 2003 and went to work trying to rebuild the country’s health infrastructure first for the Red Cross and then on behalf of the U.S. government. She lived in constant danger for many years and proved adept at moving between the U.S., Iraqi and Iranian powers because of her unique approach to problem-solving.
More recently, Prouse has worked in Silicon Valley, including a stint at Google where she found complaints from the workforce about the quality of the quinoa and sushi quite comical.
As if her career was not dramatic enough, Prouse also survived a brain tumor during what were meant to be her easier years.
We discuss all of this in the show, using Prouse’s best-selling memoir as a guide through her journey.
The Core Memory podcast is on all major platforms and on our YouTube channel over here. If you enjoy the show, please leave a review and tell your friends.
This podcast is sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.
We run on Brex and so should you. Learn more about Brex right here.
The podcast is also made possible by E1 Ventures, which backs the most ambitious founders and start-ups.'



This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe

Ed Boyden has spent the last twenty or so years building the technology needed to create a working simulation of living systems. Put another way – he’s been trying to turn biology into physics.
Boyden has helped develop new techniques for imaging the brain and the body, including optogenetics and expansion microscopy. He’s also known for nurturing all-star talent at his lab at MIT and he and his students have gone on to form numerous bio-tech start-ups. Overall, Boyden is regarded as one of the top scientific minds of this era.
It was a genuine honor to have Boyden on the show, and we’re sure you’ll enjoy this episode.
In this episode, filmed at Boyden’s office, we discuss his background as a child prodigy, his work and what it might actually mean to engineer something like a mind or consciousness. We also get into Boyden’s skepticism around current large language models and the state of science funding in the U.S.
The Core Memory podcast is on all major platforms and on our YouTube channel over here. If you enjoy the show, please leave a review and tell your friends.
This podcast is sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.
We run on Brex and so should you. Learn more about Brex right here.
The podcast is also made possible by E1 Ventures, which backs the most ambitious founders and start-ups.



This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe

We do not usually do venture capitalists on the Core Memory podcast. They can be a lot and like to hear themselves talk a bit too much. (Not you! The other ones – Ed.)
But, for Peter Barrett, we will always make an exception. He’s a general partner at Playground Global and is one of those people who knows an awful lot about an awful lot of things. He is one of my favorite people to listen to and gets my mind racing with tons of new ideas every time we speak.
Self-taught, Peter spent the early part of his career as a force of nature in the software industry. He was visited by the Men In Black as a teenager. He helped start Rocket Science Games, which was the hottest video game maker in town before it wasn’t. While there, Peter happened to employ a young intern named Elon Musk. . .
Later, Peter would be part of the team that created WebTV and a longtime distinguished engineer at Microsoft, working alongside Bill Gates and Steve Ballmer.
These days Peter goes deep on deep tech at Playground. As such, we talk quantum computing, the insane world of AI agents, nuclear power, data centers in space (and why they won’t work) and whether or not humans should be in total panic.
The Core Memory podcast is on all major platforms and on our YouTube channel over here. If you enjoy the show, please leave a review and tell your friends.
This podcast is sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.
We run on Brex and so should you. Learn more about Brex right here.
The podcast is also made possible by E1 Ventures, which backs the most ambitious founders and start-ups.


This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe

The center of the universe has been born again. The most insufferable posters on our timeline, including myself, are enjoying the abundance found in San Francisco thanks to the AI boom lining the pockets of fresh college dropouts. The themed parties are bumping, the LLMs look good, the La Croix is flowing. There is much doom in this world, but not in this podcast.
On this episode of the Core Memory podcast, we’re joined by Jayden Clark. He’s the host of Members of Technical Staff, a podcast about niche San Francisco tech culture. He’s been featured in the New Yorker, The New York Times, and Business Insider. We discuss all the important parts of life in this new version of San Francisco: themed parties, online discourse, and the permanent underclass.
The Core Memory podcast is on all major platforms and on our YouTube channel over here. If you enjoy the show, please leave a review and tell your friends.
This podcast is sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.
We run on Brex and so should you. Learn more about Brex right here.
The podcast is also made possible by E1 Ventures, which backs the most ambitious founders and start-ups.



This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe

Let’s get right to the point: Nobel Prize winner Jennifer Doudna is on the pod this week.
Doudna won the 2020 Nobel Prize in Chemistry alongside Emmanuelle Charpentier for their work developing “a method for high-precision genome editing.” They, and others, helped usher in the CRISPR revolution with people getting very, very excited about the prospects of editing genes in humans, animals, and plants with more precision and ease.
There have been some massive recent CRISPR wins. Casgevy, which treats sickle cell disease, emerged as the first FDA-approved CRISPR therapy. And, last year, an infant in Pennsylvania had a rare disease treated with record-breaking speed via CRISPR technology.
That said, CRISPR has, in many ways, not lived up to the hope and hype just yet. CRISPR therapies remain expensive and tough to distribute throughout the body.
Doudna is convinced that several major CRISPR breakthroughs are upon us, and we get into where she sees the field going. We discuss the work she’s doing at start-ups and the Innovative Genomics Institute – a research powerhouse that links UC Berkeley, UC San Francisco, and UC Davis.
And we talk about Pomona College, our shared alma mater, rejecting our wonderful, brilliant children who will no doubt go on to do amazing things in the world and likely make untold billions that will be donated to other tremendous institutions. JK. Chirp, chirp!
If you want to get up to speed on gene editing’s present and future, you will not find a better discussion.
The Core Memory podcast is on all major platforms and on our YouTube channel over here. If you enjoy the show, please leave a review and tell your friends.
This podcast is sponsored by Brex, the intelligent finance platform built to help companies spend smarter and move faster.
We run on Brex and so should you. Learn more about Brex right here.
The podcast is also made possible by E1 Ventures, which backs the most ambitious founders (probably some peptide users) and start-ups.


This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.corememory.com/subscribe