Discovery

The rapid spread of antibiotic resistant bacteria is already claiming lives - and a far greater global crisis is on the horizon.
In this three part series for Discovery, reporter Roland Pease traces how we reached this point, uncovers the forces driving resistance ever faster, and meets the scientists racing to outpace evolving superbugs before our lifesaving medicines fail for good.
Episode 2 - The chemists' challenge. With all the low-hanging fruit in the antibiotic search space gone, chemists are having to work harder and be cleverer to top up the antibiotic pipeline. The chances of finding even one successful compound in a working life are low, but can new approaches like AI or genetics make the difference?

The rapid spread of antibiotic resistant bacteria is already claiming lives and a far greater global crisis is on the horizon. In the first episode of a three-part series, reporter Roland Pease traces the rise of resistance since the discovery of penicillin, its consequences for patients, and how bacteria are getting widening the treatment gap.

Ever heard of the unsuccessful Dutch painter who decided to humiliate his critics by forging Vermeers, which the artworld subsequently dubbed 'masterpieces'? Or the businessman who bought a Marc Chagall painting that he displayed with pride for years, before a television investigation revealed to his horror that it was a fake? Today we're exploring the scientific techniques used to reveal forged artworks - and bring down scammers still trying to make millions from fake masterpieces. Jehane Ragai is an Emeritus Professor of Chemistry at the American University in Cairo, with a passion for science matched by her love of arts and culture. Early in her career Jehane helped analyse the Great Sphinx of Giza and later became fascinated by the world of art forgery, leading to her acclaimed book, ‘The Scientist and the Forger’. Her life has not been without its difficulties, but - perhaps unsurprisingly, as the daughter of renowned Egyptian feminist Doria Shafik - she’s not one to shy away from a challenge. And as she tells Professor Jim Al-Khalili, Jehane feels priveleged to have been able to integrate her twin passions into a career; advice she now passes on to her students

Tony Juniper is an environmentalist who has worn many hats, over the course of his career. After developing a passion for birds in childhood, his first job saw him working to save endangered parrots - including a successful effort to bring back the Spix's macaw from the edge of extinction. Tony went on to hold leading campaigning roles with some of the world's best known environmental organisations, from Friends of The Earth to the World Wildlife Fund. He also acted as an advisor to King Charles's International Sustainability Unit and co-authored three books with the monarch. Today, Tony has swapped lobbying and campaigning for advising the government, as head of the advisory body Natural England: not without its challenges, but he says they are still outweighed by the positives. Talking to Professor Jim Al-Khalili about his enduring love for nature and hopes for the future, Tony explains his optimism that we can and will recognise the urgent need to protect and restore our planet; and why ultimately, that means saving ourselves.

The COP30 climate summit is taking place in the Brazilian city of Belém, a gateway to the Amazon rainforest, which continues to face widespread deforestation. We all know that our climate is changing and that we are largely responsible for this, but we can’t tackle the problem unless we understand what’s going on.
One scientist who’s done more than most to rectify this is Professor Pierre Friedlingstein. He’s a prominent climate scientist and Chair in Mathematical Modelling of the Climate System at Exeter University. His models have transformed our understanding of climate change, revealing a complex dynamical system with carbon at its centre, cycling between the atmosphere, oceans and land, to directly influence the level of carbon dioxide in the atmosphere.
Pierre is actively involved in assessing the state of our climate through the Intergovernmental Panel on Climate Change and, as director of the Global Carbon Budget, estimates the remaining amount of carbon dioxide that can be emitted before we breach our global climate targets. It’s the ultimate test of effective climate action and the latest annual update will be released at COP.
Pierre explains how we can all play our part to reduce carbon emissions, and he practises what he preaches - he won’t be flying to COP this year so as to minimise his own carbon footprint.