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The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey
The Human Upgrade: Biohacking for Longevity & Performance
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  • Still Fasting in 2025? Here’s How to Make It Work Better : 1315
    How do you activate your body’s natural repair system? How can you hack stem cells for faster recovery, brain optimization, and peak human performance? This episode reveals how to trigger stem cell release, direct them to the right tissues, and stack biohacking tools for maximum regeneration. You’ll learn science-backed strategies for boosting mitochondria, enhancing neuroplasticity, and extending longevity through targeted supplements, fasting, and functional medicine techniques. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey talks with Christian Drapeau, a leading stem cell scientist and founder of STEMREGEN. Christian’s decades of research have transformed our understanding of how stem cells repair the body, reverse damage, and amplify performance. He shares practical protocols to mobilize stem cells, improve microcirculation, and reduce inflammation so your body heals faster, functions better, and stays younger for longer. You’ll learn: • How stem cells rebuild muscle, brain, and organ tissue for optimal human performance • Why fasting rejuvenates bone marrow and increases stem cell effectiveness • The synergy between PEMF, vibration therapy, cold therapy, and stem cell activation • How microcirculation and inflammation control improve longevity and recovery • The best supplements and nutrients to support mitochondria and stem cell health • How to stack nootropics, ketosis, and brain optimization tools for lasting energy and focus This is essential listening for anyone serious about biohacking, longevity, human performance, mitochondria health, neuroplasticity, functional medicine, fasting protocols, supplements for recovery, brain optimization, smarter not harder healing, metabolism upgrades, cold therapy stacks, and next-level physical and cognitive resilience Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: STEMREGEN, biohacking, natural stem cell activation, human performance, longevity, mitochondria, neuroplasticity, fasting, bone marrow rejuvenation, functional medicine, supplements, brain optimization, metabolism, cold therapy, microcirculation, nootropics, ketosis, smarter not harder, recovery hacks Resources: • STEMREGEN Website: https://www.stemregen.co/dave for 20% off your first order. • Dave Asprey’s Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:00 — Why Some People Regenerate Better 1:52 — Testing Stem Cell Levels 2:58 — Natural Stem Cell Function 3:59 — Exercise & Stem Cell Response 5:13 — Tissue Turnover & Regeneration 7:03 — Bone Marrow Production 8:16 — Fasting & Bone Marrow 9:33 — Nutrition for Bone Marrow 11:14 — Traditional Meets Modern Science 12:58 — Training Bone Marrow 13:57 — Stem Cells as Repair System 34:20 — Stem Cells & Brain Injury 47:01 — Inside STEMREGEN Products 55:41 — Stress, Cortisol & Stem Cells 58:12 — Final Recommendations See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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  • How to Make Life-Changing Decisions Without Fear – Joe Hudson : 1314
    How do you make tough decisions? How do you make them without fear or lying? This episode shows you how unresolved emotions disrupt decision-making, relationships, and functioning in peak brain performance. You’ll learn tips to rewire your nervous system for decision making, optimizing emotional intelligence, and regulating your body for high-level clarity, energy, and resilience. Discover biohacking techniques that use emotional release and somatic awareness to boost mitochondria, activate neuroplasticity, and achieve lasting personal transformation. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey talks with Joe Hudson, a world-renowned executive coach to unicorn founders and billion-dollar leaders. Joe works with a select group of top performers to unlock emotional clarity, leadership mastery, and deep personal change. His methods combine neuroscience, trauma healing, somatic therapy, and conscious coaching to help people perform at their highest level while becoming more authentic, fulfilled, and connected.You’ll learn:• How emotional repression affects brain function, metabolism, and decision-making • Tools for nervous system regulation and emotional healing that drive high performance • Why most people fail without emotional intelligence and internal safety • How somatic awareness can optimize your energy, focus, and relationships • The science of fear, trauma release, and how to turn discomfort into growth • How to coach yourself out of stress, shame, and negative self-talk This is essential listening for anyone serious about emotional intelligence, high-performance coaching, biohacking, somatic healing, trauma work, executive leadership, nervous system regulation, brain optimization, functional medicine, and building unstoppable inner resilience. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: Joe Hudson, Dave Asprey, emotional intelligence, nervous system regulation, somatic therapy, trauma healing, executive coaching, biohacking emotions, brain optimization, emotional mastery, making tough decisions, fear or failure, leadership development, negative self talk, childhood trauma, personal transformation, smarter not harder, stress relief tools, leadership listening Thank you to our sponsors! Puori | Head to http://puori.com/dave for 20% off, including subscriptions. Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. Active Skin Repair | Visit http://activeskinrepair.com/ to learn more and use code DAVE to get 20% off your order. Resources: • Sign up for a complimentary transformation guide from Joe: https://www.artofaccomplishment.com/ • Joe’s Art of Accomplishment Podcast: https://open.spotify.com/show/6MjoHFfLmNgo0Msais7IJ2 • Daily Insights on Twitter: https://tinyurl.com/4kazb783 • Dave Asprey’s Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Introduction 2:42 — Why We Struggle with Fasting 6:28 — Identity and Control Patterns 11:56 — The Nervous System and Decision-Making 23:33 — Letting Go vs. Forcing Change 28:09 — Rebuilding Every Organ with Anti-Aging Work 33:51 — How to Actually Feel Emotions (Without Getting Stuck) 39:18 — Upgrading the Subconscious 45:02 — Final Thoughts and Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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  • The New Poisons Lurking Around You – Save Your Longevity : 1313
    Toxins you cannot see are damaging your health, wrecking your metabolism, and quietly accelerating aging. This episode reveals how to detect the new poisons lurking in your home, how they sabotage mitochondria and brain optimization, and the biohacking fixes that restore longevity, energy, and human performance. You’ll learn actionable strategies you can implement right away, from functional medicine detox protocols to supplements that protect your nervous system and upgrade neuroplasticity. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Alan Bell, an environmental health attorney and author of POISONED. Alan’s landmark legal work and decades of investigative experience have exposed some of the most dangerous everyday chemicals in modern life. After surviving his own severe toxic exposure, he’s dedicated his career to helping others identify hidden threats, fight back against corporate negligence, and restore their health through targeted biohacking and functional medicine. You’ll learn: • The most common invisible poisons in homes and how they impact metabolism, mitochondria, and brain optimization • Biohacking techniques for detox, from supplements to fasting and cold therapy • How to protect longevity and human performance with targeted functional medicine strategies • Why your sleep optimization, ketosis, and nootropics stack may fail without toxin removal • The connection between environmental toxins, neuroplasticity, and emotional resilience • How to use smarter not harder thinking to upgrade your biology for the long term This is essential listening for anyone serious about biohacking, brain optimization, hormone hacking, nootropics, functional medicine, emotional resilience, and building a state of unstoppable energy. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: Alan Bell, Dave Asprey, environmental illness, toxic building syndrome, VOC exposure, multiple chemical sensitivity, U.S. chemical safety laws, environmental toxins, mast cell activation, mitochondrial health, ten most dangerous chemicals, biohacking detox, air filtration, flame retardant-free bedding, non-toxic cookware, chronic illness Thank you to our sponsors! Get 15% off your first purchase at https://oneskin.co/ASPREY with code ASPREY.BON CHARGE | Go to https://boncharge.com and use code DAVE for 15% off. Calroy | Head to https://calroy.com/dave for an exclusive discount. Resources: • Alan’s Website: https://alanbell.me/ • Dave Asprey’s Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:07 — Intro 3:45 — Life in a Bubble 5:40 — Building Syndrome Impact 7:04 — Legal Gaps 11:55 — Medical Blind Spots 13:04 — Chemicals + Mold 14:00 — Legal Barriers 17:15 — Environmental Disease Links 18:54 — Toxic Burden 20:53 — Media Awareness 21:55 — Hollywood Hazards 24:00 — MCS & Fibromyalgia 26:04 — Recovery Strategies 27:22 — Mast Cell Science 38:15 — Biohacking & AI 40:17 — Top 10 Chemicals 44:00 — Reduce Exposure 48:45 — Detox & Travel 50:20 — Legal + Media Power 52:33 — Chemical Industry Truth 56:19 — Policy & Advocacy 58:12 — Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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  • Jim Kwik: What I Take to Biohack Brain Speed and Focus : 1312
    Want to think faster, remember more, and rewire your brain for high performance? This special archived episode breaks down the real nootropic stack, neuroplasticity tools, and brain optimization protocols Jim Kwik uses daily, plus the biohacking routines that rebuilt his cognition after traumatic brain injury. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with world-renowned brain coach Jim Kwik, bestselling author of Limitless and advisor to billionaires, athletes, and Hollywood performers. After being labeled “the boy with the broken brain” as a child, Jim transformed his life through functional medicine, nootropics, cold therapy, neurorehab, and smart supplementation. He’s now the go-to expert on learning how to learn, with cutting-edge insights on memory, speed reading, focus, and cognitive recovery. Together, they reveal the most effective supplements for brain optimization, how to stack smart drugs with sleep optimization, the surprising downside of alpha GPC, and why things like ketosis, mitochondrial support, and even Danger Coffee are essential for modern cognition. You’ll also hear why your brain speed depends on your metabolism, the forgotten science of post-traumatic growth, and how to combine breathing, fasting, and cold therapy for massive neuroplasticity gains. Jim also shares his Brain Animal system, a new way to personalize your learning, decision-making, and communication based on your unique cognitive style. From performance to parenting, he shows how your “brain type” influences every part of life and how to hack it for focus, clarity, and flow. This episode is packed with high-impact strategies for biohacking your brain, improving human performance, upgrading memory, and building real resilience using smarter not harder protocols. You’ll Learn: • What Jim Kwik takes daily for brain speed, cognition, and mental stamina • The exact nootropics Dave Asprey uses (and the ones he avoids) • How sleep apnea nearly destroyed Jim’s performance and how he hacked it • The connection between mitochondria, memory, and metabolism • Why brain inflammation blocks focus and cognitive clarity • When to use cold therapy, hyperbaric oxygen, and stem cells for brain repair • How to know if your brain needs more acetylcholine and what happens if you overdo it • The best biohacking tools for focus, speed reading, learning, and flow state • Why your brain animal determines how you learn, lead, and connect Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keyword Index: Acetylcholine supplements, Alpha GPC vs CDP choline, Post-traumatic growth brain, Stem cells for brain repair, Hyperbaric oxygen therapy for TBI, Brain inflammation supplements, Learning disabilities recovery, Best supplements for neurogenesis, Brain fog biohacks, Brainwave training programs, Smart drug protocols, Cognitive stack routines, Mitochondrial support for cognition, Electrolytes for brain performance, Danger Coffee brain benefits, ADHD nootropics protocol, Sleep apnea and cognition, High dopamine supplements, Brain types and learning styles, Upgrade Labs review Thank you to our sponsors! Generation Lab | Go to http://generationlab.com/, use code Dave20 for $20 off, and see what your body’s really doing behind the surface. GOT MOLD? | Go to http://gotmold.com/shop and use DAVE10 to save 10% and see what’s in your air. BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 to save 20% off your first order of PerfectAmino. Resources: • Jim's Website: https://www.jimkwik.com/ • Dave Asprey’s Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: • 0:00 — Introduction & Brain Health • 0:47 — Childhood Injury & Struggles • 2:53 — Adversity & Purpose • 6:31 — Nootropics & Optimization • 18:49 — Daily Biohacking Habits • 32:14 — Exercise & Brain Function • 34:21 — Learning & Cognition • 38:06 — Sleep & Resilience • 41:41 — Brain Types Explained • 52:16 — Parenting & Neuroplasticity • 57:19 — Limitless Update & Wrap-Up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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  • Why I Inject a “Female Hormone” 3x a Week (Nootropic Hacking) : 1311
    What if the most powerful upgrades for brain energy, metabolism, and drive aren’t in mainstream medicine, but in rare peptides and misunderstood hormones? In this episode, you’ll discover the cutting-edge compounds, nootropics, and hormonal strategies that elite biohackers are using right now to optimize every part of their biology. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Jay Campbell and Hunter Williams, co-founders of BioLongevity Labs—a performance biotech company creating oral peptide-based products like BioMind and BioGutPro. Jay is a globally recognized expert in testosterone optimization, author of The TOT Bible, and a leading voice in hormone and peptide therapeutics. Hunter is a high-performance coach and podcast host focused on metabolism, mindset, and men’s health through functional medicine and advanced supplementation. In this high-energy, high-clarity conversation, the trio explore what’s working right now in advanced human performance, spanning hormone synergy, mitochondrial enhancement, libido compounds, nootropics, and muscle-preserving stacks. You’ll hear why Dave injects estradiol three times per week, how Jay and Hunter use oral bioregulators to improve gut-brain signaling, and what peptides are quietly reshaping the future of health. You’ll Learn: • Who should use estradiol—and how it can protect brain performance in men • The real role of testosterone and estradiol synergy in male health and longevity • How BioLongevity Labs is innovating with oral peptide delivery for cognitive and gut health • Why peptides like BPC‑157, TB‑500, PT‑141, and SS‑31 are changing mitochondrial care • The truth about Melanotan‑1, SLU, AOD‑9604, GW‑501516, and BAM‑15 • What makes BioMind and BioGutPro different from standard nootropic or probiotic stacks • Why libido and metabolic health are deeply connected • The dangers of unvetted peptide sources—and what to look for in quality and bioavailability This is essential listening for anyone serious about biohacking, hormone optimization, mitochondrial support, brain energy, nootropics, neuroplasticity, functional medicine, sleep optimization, metabolism, and smarter-not-harder living. Keyword Index: estradiol for men, Dave Asprey hormone therapy, Jay Campbell BioLongevity Labs, Hunter Williams performance coaching, BPC‑157 recovery peptide, TB‑500 tissue regeneration, PT‑141 libido peptide, SS‑31 mitochondria peptide, Melanotan‑1 for skin and mitochondria, SLU stack, AOD‑9604 fat loss peptide, GW‑501516 Cardarine, BAM‑15 mitochondrial uncoupler, oral peptide delivery, BioMind brain supplement, BioGutPro gut-brain axis, testosterone estradiol synergy, mitochondrial uncoupling, nootropic peptide stacks, performance biohacking supplements Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Thank you to our sponsors! Puori | Head to http://puori.com/dave for 20% off, including subscriptions. Leela Quantum Tech | Head to https://leelaq.com/DAVE for 10% off. ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. Resources: • BioLongevity Labs Website: https://biolongevitylabs.com/?ref=DAVE# • Dave Asprey’s Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 00:00 – Trailer 01:00 – Introduction & Early Days of Biohacking 02:03 – Peptides 101: Foundations and Frameworks 03:06 – Peptides for Healing, Cognition, and Longevity 07:56 – Bioregulators and Russian Innovations 11:07 – Side Effects and Safety of Peptides 22:27 – Oral Peptides and Product Innovations 27:41 – Body Composition, Hormones, and Fat Loss 32:02 – Testosterone, Estrogen, and Male Health Protocols 45:03 – Peptides for Performance, Fat Loss, and Longevity 1:26:32 – Loose Skin, Surgery, and Body Transformation 1:38:00 – Closing Thoughts & Product Recommendations See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Om The Human Upgrade: Biohacking for Longevity & Performance

For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own performance and embrace possibility with The Human Upgrade™.You’ll meet bright thinkers and radical doers who push the boundaries of science, technology, personal development, and human performance in every way imaginable. You’ll learn from experts around the world who elevate what it means to be human.Every guest you listen to, every topic you learn about, every new idea you discover on this podcast moves you forward.Join The Human Upgrade™ with Dave Asprey on this next evolution to upgrade your mind, body and life.
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