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The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey
The Human Upgrade: Biohacking for Longevity & Performance
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  • The Human Upgrade: Biohacking for Longevity & Performance

    Combine Creatine With THIS To Fight The Root Cause of Aging | Andrew Salzman : 1474

    2026-05-28 | 1 h 23 min.
    How CD38, PARP, and Leaky Gut Are Destroying Your NAD Levels | Dr. Andrew Salzman

    Your NAD is being drained by two hidden enzymes, your gut may be the starting point of every aging process in your body, and creatine does something to your mitochondria that has nothing to do with muscle. This episode rewrites what you thought you knew about longevity, anti-aging biology, and how your body actually produces and delivers energy at the cellular level.

    -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR
    -Explore all of Wonderfeel’s products at: getwonderfeel.com/dave

    Host Dave Asprey sits down with Dr. Andrew Salzman, a physician, inventor, and biomedical entrepreneur with more than 30 years of experience in drug discovery and development. An alumnus of Harvard Medical School, Yale University, and Columbia University, Dr. Salzman has authored more than 170 scientific publications and holds 50 patents. He invented the original clinical-stage PARP-1 inhibitor, leading to the world's first clinical treatment for raising NAD levels and fighting cancers caused by the BRCA1 and BRCA2 genes. Genentech licensed his breakthrough technology for $600 million. His research into gastrointestinal microbiota, autoimmune disease, oxidative stress, and mitochondrial ATP production now forms the foundation of how millions of patients get treated worldwide.

    Dr. Salzman names the two biggest NAD drains in your body, CD38 and PARP, and explains why taking NMN or NR alone is like filling a bathtub with the drain wide open. He breaks down the formulation science behind pairing NAD precursors with CD38 blockers like hydroxytyrosol alongside PARP-reducing antioxidants like ergothioneine, and delivers a paradigm-shifting explanation of creatine as an energy distribution network inside your cells. Rather than a simple muscle supplement, creatine acts as a high-speed ATP shuttle that carries energy from your mitochondria to the precise location and moment your brain, gut, and heart need it most.

    You'll Learn:
    Why NAD declines with age and which two enzymes are primarily responsible for draining it
    How CD38 rises with inflammation rather than NAD levels, and what that means for your supplement strategy
    Why creatine is one of the most underrated anti-aging and brain optimization supplements available
    How creatine functions as a spatial and temporal energy delivery network for your brain, gut, and heart
    Why the gut may be the origin point of the entire aging process and how that cascade unfolds decade by decade
    How leaky gut drives systemic inflammation, crashes NAD, and accelerates biological aging throughout the body
    What controls tight junction integrity and how ATP, butyrate, creatine, and fasting all play a role
    Why most creatine supplements fail to absorb properly and what to look for in a high-quality source
    How to rebuild your microbiome in three to four weeks through diet alone, without antibiotics
    Why walking immediately after a meal may be doing more harm than good to your gut lining


    Thank you to our sponsors!
    - Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave.
    - KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off
    - Pique | Go to Piquelife.com/dave for 20% off.
    - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE


    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

    Keywords: Dr. Andrew Salzman, NAD depletion, CD38 inhibition, PARP inhibition, NMN supplements, creatine ATP shuttle, leaky gut aging, tight junction integrity, inflammaging, lipopolysaccharide gut, flagellin toxin, butyrate gut healing, ergothioneine, hydroxytyrosol, peroxynitrite, superoxide mitochondria, creatine energy distribution, gut origin of aging, NAD bathtub analogy, BRCA PARP inhibitor, Wonderfeel, creatine monohydrate, intestinal permeability, microbiome butyrate, selective digestive decontamination, TMAO nitric oxide


    Resources:
    • Explore all of Wonderfeel’s products at: getwonderfeel.com/dave
    • Order Youngr™: getwonderfeel.com/dave
    • Order ChocoCreatin™: getwonderfeel.com/dave
    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
    • Danger Coffee: https://dangercoffee.com/discount/dave15
    • My Daily Supplements: SuppGrade Labs (15% Off)
    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
    • Dave Asprey’s BEYOND Conference: https://beyondconference.com
    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
    • Upgrade Labs: https://upgradelabs.com


    Timestamps:
    00:00 – Trailer
    01:12 – Introduction & BRCA Background
    02:19 – DNA Damage & PARP
    04:38 – Free Radicals & Oxidative Stress
    11:37 – NAD & Antioxidant Defense
    12:34 – CD38 & NAD Depletion
    23:31 – The Gut-Aging Hypothesis
    30:05 – ATP, Creatine & Energy Distribution
    36:41 – Creatine as Energy Shuttle
    51:09 – Microbiome & Gut Repair
    59:21 – TMAO & Nitric Oxide Interference
    1:03:52 – Flagellin & Gut Inflammation Research
    1:09:45 – FDA & Pharmaceutical Incentives
    1:16:05 – Closing
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
  • The Human Upgrade: Biohacking for Longevity & Performance

    The Doctor With Answers To Your Mystery Symptoms | Jessica Peatross : 1473

    2026-05-26 | 1 h 16 min.
    The Hidden Causes of Brain Fog, Anxiety, and Chronic Illness: Mold, Parasites, Histamine, and Low Cortisol

    If you're exhausted, inflamed, and can't figure out why, the answer might be hiding in your histamine, your hormones, your home, or something living inside you that your doctor will never test for.


    Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR


    Host Dave Asprey sits down with Dr. Jessica Peatross, a former hospitalist turned functional medicine powerhouse who walked away from a conventional medical career after discovering that 90% of disease traces back to lifestyle, environment, and the toxins most doctors ignore. After graduating magna cum laude and earning her medical degree from the University of Louisville, Dr. Jess pursued training in functional medicine, nutrigenomics, and alternative therapies, and now helps thousands of patients reverse chronic illness through her KillBindSweat method and WellnessPlus app. She is also the formulator and CMO of Aegis Formulas and a leading voice at international health conferences. If chronic illness, mold toxicity, or hormonal chaos is on your radar, she is the person you want in your corner.


    Together, Dave and Dr. Jess go deep into the hidden drivers of mystery symptoms that functional medicine is finally starting to crack open. They cover why low cortisol is more dangerous than high cortisol, how histamine and mast cell activation syndrome explain everything from anxiety and brain fog to endometriosis and POTS, and why most "Lyme disease" is actually undiagnosed mold toxicity. They also break down the parasite epidemic hiding in plain sight across the United States, the B vitamin mistake making millions of people sicker, and why your metabolism, mitochondria, and mental health are all downstream of things your standard lab panel will never catch.


    This episode also gets into the real story behind Dr. Jess surrendering her California medical license rather than comply with a system she believed was working against patient health. Her firsthand account of the medical board process is something every person who cares about medical freedom needs to hear.


    You'll Learn:
    Why everyone who is chronically sick has a low cortisol awakening response and what to do about it
    How histamine drives anxiety, racing thoughts, palpitations, bloating, skin issues, and hormonal chaos
    Why 90% of people diagnosed with Lyme disease actually have toxic mold and how to test for both
    The parasite epidemic in the U.S. and why standard testing misses most of it
    How the spike protein reactivates dormant viruses and feeds the histamine loop behind long COVID
    Why synthetic B6 causes the very neuropathy it is supposed to fix, and what to take instead
    The cortisol, adrenaline, and blood pressure connection that explains "wired but tired"
    How progesterone stabilizes mast cells and why estrogen dominance fuels inflammation and reactivity
    Why Dave Asprey uses low-dose cortisol, dexamethasone, and modafinil as part of his daily performance stack
    The mold binders that actually work, and which popular ones can harm hypermobile people
    How nicotine at low doses blocks spike protein from ACE2 receptors and protects the brain
    What the MTHFR gene, methylation, and folic acid have to do with breast cancer, depression, and estrogen detox


    Thank you to our sponsors!
    - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE
    - KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off
    - Calroy | Go to Calroy.com/DAVE for exclusive discounts on Arterosil HP, Vascanox HP and all Calroy products.
    - Cowboy Colostrum | Get your gut right by going to cowboycolostrum.com/asprey for 25% off of your entire order.
    -Amp | If you're ready to make fitness fit into your life, go to amp.ai to check it out

    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


    Keywords: Dr. Jessica Peatross, functional medicine, mast cell activation syndrome, histamine intolerance, long COVID brain fog, mold toxicity, chronic Lyme disease, parasite testing, low cortisol, cortisol awakening response, MTHFR methylation, B6 toxicity, P5P, folinic acid, estrogen dominance, progesterone therapy, spike protein reactivation, Epstein-Barr reactivation, POTS, wired but tired, Kill Bind Sweat, WellnessPlus, vaccine exemptions, mold binders, nicotine ACE2, adrenal insufficiency, RCCX gene


    Resources:
    • Go to https://drjessmd.com/ and use code ‘DRJESS’ at checkout
    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
    • Danger Coffee: https://dangercoffee.com/discount/dave15
    • My Daily Supplements: SuppGrade Labs (15% Off)
    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
    • Dave Asprey’s BEYOND Conference: https://beyondconference.com
    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
    • Upgrade Labs: https://upgradelabs.com


    Timestamps:
    00:00 – Trailer
    00:33 – Releasing Medical License
    03:21 – Chronic Illness Root Causes
    05:00 – Hospital Nutrition
    08:11 – Dave's Health History
    10:22 – Parasites
    20:02 – Nicotine
    23:19 – Low Blood Pressure & Minerals
    28:09 – B Vitamins & Methylation
    33:45 – Autism & Genetics
    40:13 – Toxic Mold
    43:11 – ADHD Misdiagnosis
    48:27 – Histamine & Mast Cells
    50:56 – Long COVID & Spike Protein
    58:56 – Cortisol
    1:03:56 – Lyme Disease
    1:09:58 – Mold Testing & Binders
    1:16:37 – Closing
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
  • The Human Upgrade: Biohacking for Longevity & Performance

    The EXACT Japanese Formula To Live Past 100+ (Simple Steps) : 1471

    2026-05-24 | 9 min.
    In this video, I break down the exact biological mechanisms keeping men in Okinawa, Japan, physically dominant and mentally sharp past 100. You don't need million-dollar lab work or intense weight training to reverse your biological age. Instead, these centenarians leverage five specific lifestyle protocols to naturally upgrade their biology. I explain the hard science behind how eating to 80% full shuts down the constant growth signaling that accelerates cellular aging. We'll also cover why the modern concept of retirement physically destroys your brain function within 2-3 years, and how specific social structures actually drop inflammatory chemicals in your body by up to 30%.

    Thank you to our sponsors!
    TRU KAVA | Head to trukava.com and use code DAVE10 for 10% off.
    Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade.
    iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

    Timestamps:
    00:00 – Intro
    00:47 – Okinawa's Origins
    01:28 – Hara Hachibu (80% Full)
    02:36 – Ikigai (Purpose)
    03:57 – Never Retire
    05:19 – Social Bonds (Moai)
    07:13 – Stress Resilience
    08:54 – The 5 Habits

    Connect with Dave Asprey!

    Website: https://daveasprey.com
    TikTok: https://www.tiktok.com/@daveaspreyofficial
    Instagram: https://www.instagram.com/dave.asprey/
    Facebook: https://www.facebook.com/Daveaspreyofficial/
    X: https://x.com/daveasprey
    YouTube: https://www.youtube.com/c/daveaspreybpr

    The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

    Danger Coffee: https://dangercoffee.com/DAVE15
    Dave Asprey’s BEYOND Conference: https://beyondconference.com/
    Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
    Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15
    Upgrade Labs: https://upgradelabs.com
    40 Years of Zen: https://40yearsofzen.com
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
  • The Human Upgrade: Biohacking for Longevity & Performance

    This Epic Device Gives You A SUPERBRAIN : 1472

    2026-05-22 | 15 min.
    Light Therapy, 40Hz Gamma & Brainwave Entrainment: How BrainTap Resets Sleep, Clears Brain Fog, and Boosts Productivity by 26%

    Your brain is being starved of the one nutrient it needs most, and it is not a supplement, not a nootropic, not a fasting protocol. It is light, and a 40 hertz flicker delivered at the right frequency can break up amyloid plaque, reset your nervous system, and get you 26 percent more productive in a single session.


    -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR
    -Go to https://braintap.com/dave/ for an exclusive offer for The Human Upgrade listeners


    Host Dave Asprey sits down with Dr. Patrick Porter, PhD, award-winning author, educator, entrepreneur, and founder of BrainTap, who has spent over 35 years at the forefront of neurotechnology helping millions of people achieve mental and emotional resilience through cutting-edge brain entrainment tools. Backed by 72 peer-reviewed studies and research conducted alongside Google, Microsoft, universities in Brazil, and veteran treatment programs, Dr. Porter is one of the most experienced and validated practitioners in applied neuroscience and brain optimization working today.


    Together, Dave and Dr. Porter break down exactly how flickering light and binaural sound delivered through the BrainTap headset feeds the brain through the electron transport chain, triggers nitric oxide release, boosts mitochondrial energy, and drives neuroplasticity through frequency following response. They cover how 40 hertz gamma light breaks up amyloid plaque and why that same frequency is linked to reversing dementia, how BrainTap reset the circadian rhythms of coal miners in under three weeks, how 490,000 students in Brazil raised their GPA using brain wave entrainment, and how AI now builds personalized 21-day brain training protocols from 3,000 available sessions. If you are serious about biohacking your brain, upgrading sleep optimization, and doing smarter not harder work on your mind, this episode delivers the science and the tools.

    You'll Learn:
    Why light is the most underrated nutrient for brain health and how BrainTap delivers it directly to every cell in your body
    How 40 hertz gamma frequency breaks up amyloid plaque, restores blood flow, and may reverse dementia and Alzheimer's progression
    Why binaural beats and isochronic tones trigger frequency following response and what that does to your focus, metabolism, and energy
    How three 10-minute BrainTap sessions per day produces 26 percent more work output according to studies with Google and Microsoft
    How BrainTap restored deep sleep and REM cycles in coal miners with destroyed circadian rhythms in under three weeks
    Why 90 percent of autistic children in one study began speaking after six weeks of pulsed light therapy targeting alpha wave production
    How AI inside BrainTap now generates personalized brain training protocols based on your specific stress, sleep, and performance goals
    Why the vagus nerve is the hidden target of BrainTap's ear lights and how triggering it drives parasympathetic recovery
    How SMR brain waves create the optimal state for focus and concentration and why elite athletes use this for both performance and academic results
    What the NeuroCheck system measures across nine parameters of the nervous system in five minutes and how it validates your biohacking results


    Thank you to our sponsors!
    - AirDoctor | Go to https://airdoctorpro.com/daveasprey and save up to $300 on Air Purifiers.
    - AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers.
    - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE


    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


    Keywords: Dr. Patrick Porter, BrainTap, brainwave entrainment, light therapy, sound therapy, binaural beats, isochronic tones, 40 hertz gamma, gamma frequency, amyloid plaque, Alzheimer's prevention, dementia reversal, neuroplasticity, brain optimization, neurotechnology, frequency following response, SMR brain waves, alpha waves, delta waves, theta waves, vagus nerve, vagal stimulation, parasympathetic nervous system, nitric oxide, mitochondria, electron transport chain, sleep optimization, circadian rhythm reset, deep sleep, REM sleep, Oura Ring, HRV, cognitive performance, focus and concentration, productivity, nootropics, brain entrainment, photobiomodulation, red light therapy, near infrared light, biohacking, human performance, anti-aging, longevity, neurohacking, mental resilience, stress reduction, anxiety relief, autism therapy, pulsed light therapy, AI personalization, personalized wellness, meditation technology, Dave Asprey, Beyond Biohacking Conference, NeuroCheck, nervous system assessment, brain health, mental performance


    Resources:
    • Go to https://braintap.com/dave/ for an exclusive offer for The Human Upgrade listeners
    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
    • Danger Coffee: https://dangercoffee.com/discount/dave15
    • My Daily Supplements: SuppGrade Labs (15% Off)
    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
    • Dave Asprey’s BEYOND Conference: https://beyondconference.com
    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
    • Upgrade Labs: https://upgradelabs.com


    Timestamps:
    00:00 – Trailer
    00:30 – Intro & Guest Welcome
    01:45 – BrainTap: Light & the Brain
    04:15 – 40Hz Gamma & Alzheimer's
    05:55 – Sound & Binaural Beats
    07:26 – Usage Protocol & Results
    08:37 – Sleep & Circadian Reset
    09:29 – AI-Personalized Sessions
    10:47 – Conference Preview
    12:19 – Vagus Nerve & Ear Lights
    13:33 – Closing & Offer
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
  • The Human Upgrade: Biohacking for Longevity & Performance

    The Biblical Anti-Aging Fruit That Scientists Are Obsessed With : 1470

    2026-05-21 | 53 min.
    The ancient fruit sitting in your grocery store right now outperforms rapamycin, rivals caloric restriction, and triggers a cellular cleanup process that most longevity scientists did not even know existed until a lab changed everything 18 years ago.


    -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR
    -Go to timeline.com/Dave or just use code ‘Dave’ to get 20% off your next order.


    Host Dave Asprey sits down with Chris Rinsch, co-founder and President of Timeline Longevity and a PhD cell biologist who has spent nearly two decades doing pharmaceutical quality clinical research on one of the most underrated longevity molecules on earth. Before founding Timeline in 2007, Rinsch worked in venture capital investing in pioneering life sciences companies and in biotechnology developing cell-based therapies at Swiss biotech company ISOTIS SA. He has authored original publications in Nature Medicine, Nature Metabolism, JAMA Open, and Cell Reports Medicine, and holds internationally filed and granted patents on urolithin A. This is the first time a Timeline co-founder has appeared on the show.


    Together, Dave and Chris break down the full science of urolithin A, the postbiotic compound unlocked from pomegranate by gut bacteria, and why it triggers mitophagy to clear out damaged mitochondria and replace them with high-functioning ones. They cover why only 30 to 40 percent of people can produce urolithin A from food alone, how one month of supplementation measurably improved immune cell populations in people aged 50 to 70, and why Dave has stacked this into his daily longevity protocol alongside NAD precursors and nootropics for years. If you are serious about biohacking your mitochondria, extending healthspan, and doing smarter not harder longevity work, this episode delivers the deep science to back it up.


    You'll Learn:
    Why urolithin A outperforms rapamycin in worm lifespan studies and rivals caloric restriction at 45 percent life extension
    How mitophagy works, why it declines with age, and why it is one of the most important anti-aging mechanisms in the body
    Why eating pomegranates or taking cheap pomegranate extract does not work for most people and what to take instead
    How one month of MitoPure improved natural killer cells, CD8 T naive cells, and reduced inflammation in adults aged 50 to 70
    Why mitochondria are central to metabolism, brain optimization, immune function, cardiovascular health, and skin aging
    How Timeline's topical urolithin A produced statistically significant reductions in fine lines and wrinkles after eight weeks
    Why Dave considers this one of the most clinically validated supplements in his longevity stack alongside NAD and fasting protocols
    How L'Oreal became a Timeline investor after confirming the mitochondrial science was unlike anything in their existing ingredient library
    What the XPRIZE Healthspan competition is targeting and why Timeline is competing to reverse biological aging by 10 to 20 years
    Why the future of functional medicine will require a mitochondrial blood test and how close we are to having one


    Thank you to our sponsors!
    - EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE
    - Calroy | Go to Calroy.com/DAVE for exclusive discounts on Arterosil HP, Vascanox HP and all Calroy products.
    - Neuronic | Go to www.neuronic.online Code DAVE for $100 off
    - ENERGYbits | If you want a simpler, smarter way to support your body… this is it. Head to ENERGYbits.com and use code ASPREY for 20% off your order.

    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


    Keywords: Chris Rinsch, Timeline Longevity, MitoPure, urolithin A, mitochondria, mitophagy, pomegranate, elagitannins, postbiotic, gut microbiome, longevity, anti-aging, healthspan, biohacking, supplements, human performance, metabolism, mitochondrial health, cellular health, autophagy, natural killer cells, immune health, inflammation, NAD, rapamycin, caloric restriction, muscle endurance, collagen, skin aging, fine lines, wrinkles, topical skincare, L'Oreal, XPRIZE Healthspan, Nature Aging, clinical trials, longevity stack, brain optimization, cardiovascular health, biological age, aging clock, fasting, nootropics, functional medicine, Dave Asprey, polyphenols, microbiome diversity


    Resources:
    • Go to timeline.com/Dave or just use code ‘Dave’ to get 20% off your next order.
    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
    • Danger Coffee: https://dangercoffee.com/discount/dave15
    • My Daily Supplements: SuppGrade Labs (15% Off)
    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
    • Dave Asprey’s BEYOND Conference: https://beyondconference.com
    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
    • Upgrade Labs: https://upgradelabs.com


    Timestamps:
    00:00 – Trailer
    00:37 – Intro
    03:57 – Pomegranates
    10:03 – Discovering Urolithin A & Mitophagy
    20:50 – Science vs. Pomegranate Supplements
    25:24 – Topical Skincare Science
    26:09 – L'Oreal Partnership & Skin Results
    33:38 – 15 Clinical Studies & XPRIZE
    43:50 – Nature Aging Immune Study
    49:22 – Dosing & Daily Routine
    51:29 – Future of Mitochondrial Health
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Om The Human Upgrade: Biohacking for Longevity & Performance
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
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