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The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey
The Human Upgrade: Biohacking for Longevity & Performance
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  • The Human Upgrade: Biohacking for Longevity & Performance

    World Cup, Sunscreen, Hair Regrowth, Caffeine Chewing Gum, and more... : 1483

    2026-06-12 | 11 min.
    Semaglutide Slows Biological Aging
    A randomized, placebo-controlled study published in Nature Communications found semaglutide slowed biological aging markers by nine percent on the DunedinPACE epigenetic clock in adults living with HIV-associated metabolic disease, with simultaneous improvements across inflammation, heart, kidney, liver, and brain markers. Host Dave Asprey breaks down why this isn't a weight loss story. It's a metabolic inflammation story. He explains why the GLP-1 mechanism hitting insulin signaling, oxidative stress, and inflammatory pathways simultaneously is the real finding, and makes the case that your metabolic markers and your aging markers are the same numbers.
    Sources:
    https://www.medicalnewstoday.com/articles/glp-1-drugs-ozempic-wegovy-may-slow-biological-aging
    https://www.nature.com/articles/s41467-026-72861-3
    https://today.ucsd.edu/story/study-popular-glp-1-drug-may-slow-down-biological-aging


    FDA Approves First New Sunscreen Ingredient in 20 Years
    The FDA approved bemotrizinol as a permitted OTC sunscreen active ingredient, the first new approval in roughly two decades, clearing it for adults and children six months and older with broad UVA and UVB coverage and low skin absorption. Host Dave Asprey explains why twenty years of regulatory lag left American consumers with inferior chemistry while Europe moved on, why he's watching independent absorption data before updating his own stack, and why consistency of use matters more than perfect formulation when sun protection remains one of the most evidence-backed longevity interventions available.
    Sources:
    https://www.fda.gov/news-events/fda-newsroom/press-announcements/fda-expands-sunscreen-options-first-time-20-years
    https://www.accessdata.fda.gov/scripts/cder/omuf/index.cfm?event=OrderDetail&orderid=OTC000039
    https://www.usatoday.com/story/news/health/2026/06/09/new-sunscreen-ingredient-bemotrizinol/90477659007/


    Deoxyribose Gel Matches Minoxidil in Hair Regrowth Study
    Researchers testing a topical gel made from deoxyribose, the sugar backbone of DNA, saw roughly 80 to 90 percent hair regrowth in a mouse model of male-pattern baldness, matching minoxidil results and showing new follicle formation and increased blood vessel activity in treated areas. Host Dave Asprey breaks down why mouse hair regrowth studies have a long history of failing to translate to humans, what a plausible circulation-based mechanism would actually need to show in human trial data before it's worth acting on, and why the molecule itself is interesting enough to keep watching.
    Sources:
    https://www.reddit.com/r/Biohackers/comments/1tyt87w/researchers_found_that_a_gel_made_from/
    https://www.sciencealert.com/surprise-hair-loss-breakthrough-a-dna-sugar-gel-sparks-robust-regrowth


    Caffeinated Chewing Gum and Exercise Performance
    A systematic review and meta-analysis of 21 studies found caffeinated chewing gum produces a small but real ergogenic effect for muscular strength and countermovement jump height, with buccal absorption delivering caffeine faster than capsules or drinks in a five to twenty-five minute pre-training window. Host Dave Asprey breaks down why delivery mechanism is an underrated variable in caffeine optimization, why timing matters as much as dose, and why a modest but measurable edge on a cheap and accessible tool is exactly the kind of practical biohack worth understanding.
    Sources:
    https://pubmed.ncbi.nlm.nih.gov/42228847/
    https://doi.org/10.1519/JSC.0000000000005530
    https://www.reddit.com/r/Biohackers/comments/1u0acgc/fastacting_caffeine_does_caffeinated_chewing_gum/


    Vitamin A Overdoses Surge Nearly 40 Percent
    Medical News Today reported a 38.7 percent spike in vitamin A overdoses in early 2025, driven by online misinformation claiming high-dose vitamin A treats or prevents measles, a claim with no clinical support and real toxicity risk from fat-soluble accumulation in the liver. Host Dave Asprey explains the actual hepatotoxicity and bone demineralization risks of preformed retinol excess, draws the critical distinction between preformed retinol and beta-carotene that got lost in the misinformation cycle, and makes the case that mechanism is not a dosing protocol and confusing the two is how people get hurt.
    Sources:
    https://www.medicalnewstoday.com/amp/articles/vitamin-a-overdoses-rose-by-38-7-2025-how-to-get-right-amount


    World Cup 2026 and Mass Gathering Health Risk
    With the 2026 FIFA World Cup underway, public health researchers are flagging dense international crowds, high-volume travel, and shared indoor and outdoor spaces as an elevated transmission environment for respiratory illness. Host Dave Asprey reframes the conversation away from germ exposure and toward immune terrain, explains why your resilience going into a high-contact environment is a variable you actually control, and lays out the pre-exposure preparation window that matters most for anyone traveling or attending large events this summer.
    Sources:
    https://www.healthline.com/health-news/2026-fifa-world-cup-health-risks-protect-yourself


    This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on GLP-1 aging biology, sunscreen chemistry and regulatory science, emerging hair regrowth research, caffeine delivery optimization, supplement toxicity risk, and immune terrain preparation for mass gathering events. Host Dave Asprey connects randomized clinical data, epigenetic clock research, consumer health regulation, and real-world optimization protocols into actionable frameworks for extending healthspan, sharpening performance, and staying ahead of the science.


    New episodes every Tuesday, Thursday, Friday, and Sunday.


    Keywords: semaglutide biological aging, GLP-1 epigenetic clock, DunedinPACE aging marker, PCGrimAge mortality risk, bemotrizinol FDA approval, new sunscreen ingredient 2026, UVA UVB broad spectrum sunscreen, deoxyribose hair gel, minoxidil alternative hair regrowth, caffeinated chewing gum performance, buccal caffeine absorption, pre-workout caffeine timing, vitamin A overdose toxicity, preformed retinol hypervitaminosis, fat-soluble vitamin accumulation, World Cup 2026 health risk, immune terrain optimization, mass gathering respiratory illness, biohacking news 2026, longevity research, Dave Asprey, The Human Upgrade


    Thank you to our sponsors!
    - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.
    - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com.
    - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE


    Resources:
    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
    • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/
    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
    • Danger Coffee: https://dangercoffee.com/discount/dave15
    • My Daily Supplements: SuppGrade Labs (15% Off)
    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
    • Dave Asprey’s BEYOND Conference: https://beyondconference.com
    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
    • Upgrade Labs: https://upgradelabs.com

    Timestamps:
    00:00 – Intro
    00:41 – Story 1: Ozempic Slows Aging Clocks
    01:53 – Story 2: New Sunscreen Approved
    03:12 – Story 3: DNA Sugar & Hair Regrowth
    04:38 – Story 4: Caffeine Gum & Performance
    06:13 – Story 5: Vitamin A Overdose Spike
    07:59 – Story 6: World Cup & Immune Prep
    09:34 – Outro
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
  • The Human Upgrade: Biohacking for Longevity & Performance

    Brain Fog, Memory Loss, and Alzheimer's Prevention | Dr. Majid Fotuhi : 1482

    2026-06-11 | 1 h 19 min.
    How to Reverse Cognitive Decline, Grow Your Hippocampus, and Protect Your Brain from Alzheimer's Disease with Nutrition, Exercise, Sleep, and Stress Reduction

    Your brain is physically shrinking right now, and most people have no idea it's happening. In this episode, you will discover the exact mechanisms behind cognitive decline, why brain fog is always treatable, and the proven strategies to grow your brain back, protect your memory, and slash your Alzheimer's risk regardless of your genetics.

    -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

    Host Dave Asprey sits down with Dr. Majid Fotuhi, a neuroscientist and neurologist who earned his PhD from Johns Hopkins University and his medical degree from Harvard Medical School. He currently serves as an adjunct professor at the Mind/Brain Institute at Johns Hopkins while also teaching at George Washington University and Harvard Medical School. With 37 years of experience in clinical practice, teaching, and neuroscience research, Dr. Fotuhi pioneered the Brain Fitness Program, a multidisciplinary approach to cognitive performance and brain vitality at any age that has produced measurable results documented in peer-reviewed journals. He is the author of three books including the bestselling The Invincible Brain and one of the world's leading experts on neuroplasticity, hippocampus growth, and successful aging. If anyone has earned the right to tell you your brain can get better, it is him.

    Dr. Fotuhi and Dave break down why Alzheimer's is not a single disease but a soup of modifiable problems, why your lab results can show "normal" while your brain is starving, and how the five pillars of brain health connect directly to longevity, mitochondria function, and human performance. They also get into the brain effects of GLP-1s, the therapeutic promise of psychedelics like psilocybin and ketamine, the role of nootropics and supplements like B12, lithium orotate, and CoQ10, and why your VO2 max may be the single most important number for brain aging. .

    You'll Learn:
    Why 97% of Alzheimer's cases involve multiple modifiable causes and what to do about each one
    How to physically grow your hippocampus through exercise, meditation, and nutrition
    Why "normal" lab ranges are actively harming millions of people and what optimal actually looks like
    The 7 everyday things that are shrinking your brain right now
    How stress, loneliness, and isolation cause measurable brain atrophy
    Which supplements including B12, lithium orotate, CoQ10, and nootropics support long-term brain health
    Why VO2 max predicts brain aging better than almost any other marker
    What psychedelics like psilocybin and ketamine actually do to your brain according to a Johns Hopkins neurologist
    How the APOE4 gene affects Alzheimer's risk and why exercise can erase that risk entirely
    Why mitochondria health is the foundation of both brain function and longevity


    Thank you to our sponsors!
    - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.
    - BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle.
    - Pique | Go to Piquelife.com/dave for 20% off.
    - BodyHealth | Visit BodyHeath.com and use code DAVE20 for 20% off your first purchase

    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

    Keywords: Majid Fotuhi, Dr. Majid Fotuhi, The Invincible Brain, brain health, cognitive decline, Alzheimer's prevention, hippocampus, neuroplasticity, brain fog, memory loss, APOE4, brain shrinkage, B12 deficiency, lithium orotate, CoQ10, nootropics, VO2 max, mitochondria, longevity, anti-aging, biohacking, brain optimization, sleep optimization, stress reduction, functional medicine, human performance, psilocybin, ketamine, GLP-1, semaglutide, telomeres, BDNF, brain training, cognitive performance

    Resources:
    • Learn More About Dr. Fotuhi’s Work At: https://drfotuhi.com/
    • Purchase Dr. Fotuhi’s New Book The Invincible Brain: https://a.co/d/0iHCgPpL
    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
    • Danger Coffee: https://dangercoffee.com/discount/dave15
    • My Daily Supplements: SuppGrade Labs (15% Off)
    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
    • Dave Asprey’s BEYOND Conference: https://beyondconference.com
    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
    • Upgrade Labs: https://upgradelabs.com

    Timestamps:
    00:00 – Trailer
    00:59 – Intro
    03:00 – Cannabis & Nicotine
    04:15 – Understanding Alzheimer's
    05:38 – Five Pillars Explained
    07:55 – Best Cognitive Training
    09:08 – Brain Size & Growth
    12:36 – B12 & Lab Ranges
    17:48 – Head-to-Toe Evaluation
    24:17 – Sex & Brain Health
    25:43 – Loneliness & Isolation
    33:59 – ApoE4 Genetics
    35:28 – Alzheimer's Declining
    48:44 – Lithium & Brain
    59:38 – VO2 Max & Fitness
    1:06:42 – Psychedelics
    1:09:38 – GLP-1s & Brain
    1:12:38 – Closing & Action Steps
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
  • The Human Upgrade: Biohacking for Longevity & Performance

    The Foods That Starve Cancer | William Li : 1481

    2026-06-09 | 1 h 3 min.
    Dr. William Li: Eat to Beat Disease, Extend Longevity, and Hack Your Vascular Health

    Your body already has a built-in cancer defense system, and the foods you eat can rival prescription drugs at activating it. In this episode, you'll discover what 720,000 living centenarians reveal about longevity, why microplastics are reaching your brain through your nose, and how your blood vessels hold the real key to biological aging.

    -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

    Host Dave Asprey sits down with Dr. William Li, an internationally renowned physician, scientist, and two-time New York Times bestselling author of "Eat to Beat Disease" and "Eat to Beat Your Diet." As President and Medical Director of the Angiogenesis Foundation, Dr. Li's groundbreaking research has led to the development of more than 40 new medical treatments impacting care for over 70 diseases including diabetes, heart disease, blindness, and obesity. His TED Talk, "Can We Eat to Starve Cancer?", has surpassed 11 million views, making him one of the most trusted voices at the intersection of functional medicine and food as medicine science.

    Together they dig into the biology of SuperAgers, the vascular markers that predict how long you'll live, and why flow-mediated dilation may be the most underrated biohacking measurement tool available today. Dave shares what happened after four separate gene therapies, including klotho and VEGF, and Dr. Li explains why your metabolism, mitochondria, and gut microbiome show up in the data on every centenarian ever studied. They also get into the microplastic crisis, the cribriform plate pathway that delivers airborne particles directly to your brain, and why your tongue is the first place your body quietly stores fat.

    You'll Learn:
    What centenarian research reveals about immune function, gut health, and vascular resilience
    Why 50% of food extracts matched or outperformed cancer drugs in head-to-head angiogenesis testing
    How microplastics travel through your nose directly to your central nervous system
    What flow-mediated dilation and pulse wave velocity tell you about your true biological age
    Why your hind-third tongue fat is an overlooked early warning sign for sleep apnea and metabolism problems
    What Dave's four gene therapies (klotho, VEGF, follistatin) actually did to his body
    How the vagus nerve connects gut health to brain optimization, stress resilience, and longevity
    Why genetics now accounts for roughly half of longevity outcomes, and what that means for the future of gene therapy
    How to use biohacking tools to compound your health the same way you compound financial returns


    Thank you to our sponsors!
    - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com.
    - Amp | If you're ready to make fitness fit into your life, go to amp.ai to check it out
    - Caldera + Lab | A small habit with big results. Go to CalderaLab.com/DAVE and use code DAVE for 20% off your first order.
    - Calroy | Go to Calroy.com/DAVE for exclusive discounts on Arterosil HP, Vascanox HP and all Calroy products.

    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

    Keywords: William Li, Dr. William Li, Eat to Beat Disease, angiogenesis, food as medicine, centenarians, SuperAgers, longevity, anti-aging, biohacking, vascular health, flow-mediated dilation, pulse wave velocity, microplastics, cribriform plate, gene therapy, klotho, VEGF, follistatin, mitochondria, metabolism, gut health, vagus nerve, sleep apnea, functional medicine, human performance, brain optimization, cancer prevention, inflammation, immune system

    Resources:
    • Learn More About Dr. Li’s Work At: https://drwilliamli.com
    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
    • Danger Coffee: https://dangercoffee.com/discount/dave15
    • My Daily Supplements: SuppGrade Labs (15% Off)
    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
    • Dave Asprey’s BEYOND Conference: https://beyondconference.com
    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
    • Upgrade Labs: https://upgradelabs.com

    Timestamps:
    00:00 – Trailer
    02:33 – William's Background
    06:21 – Food vs. Cancer Drugs
    14:09 – Gene Therapy
    23:50 – Centenarian Research
    27:41 – Stress & the Vagus Nerve
    37:31 – Vascular Health
    42:34 – Microplastics
    53:19 – Novel Biomarkers
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
  • The Human Upgrade: Biohacking for Longevity & Performance

    I Drink Fat To Look Shredded (Lost 100lbs) : 1480

    2026-06-07 | 7 min.
    I used to weigh 300 pounds. I tried every restrictive diet, became a vegan, and trained 90 minutes a day for 18 months with absolute zero results. Everything changed when I drank a cup of yak butter tea at 18,300 feet in Tibet. Within 30 seconds, my severe brain fog lifted, and my metabolism completely shifted.

    In this video, I break down exactly why adding sugar to your morning coffee is destroying your metabolism, spiking your insulin, and keeping you fat. I explain the hard science behind the alternative: blending "fat cubes" (grass-fed butter) and MCT oil into your coffee. I reveal how this specific combination of butyrate, CLA, and medium-chain triglycerides bypasses traditional digestion to go straight to your liver, instantly converting into ketones for pure brain fuel. You'll learn how eating more fat actually trains your body to burn its own stored fat, allowing me to hit 4.8% body fat at 50 years old with a biological age in my 30s—without hunger, without a 3 PM crash, and without living in the gym.

    Thank you to our sponsors!
    Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today
    Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.
    iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

    Timestamps:
    0:00 – Intro
    00:42 – Pancreatic Cancer Halted by Virus Injection
    01:44 – Teens & AI Therapy Chatbots
    03:13 – GLP-1 Drugs Cut Breast Cancer Risk
    04:30 – Russia's $26B Longevity Program
    06:18 – Sauna vs. Cold Plunge
    09:10 – Closing

    Connect with Dave Asprey!

    Website: https://daveasprey.com
    TikTok: https://www.tiktok.com/@daveaspreyofficial
    Instagram: https://www.instagram.com/dave.asprey/
    Facebook: https://www.facebook.com/Daveaspreyofficial/
    X: https://x.com/daveasprey
    YouTube: https://www.youtube.com/c/daveaspreybpr

    The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

    Danger Coffee: https://dangercoffee.com/DAVE15
    Dave Asprey’s BEYOND Conference: https://beyondconference.com/
    Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
    Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15
    Upgrade Labs: https://upgradelabs.com
    40 Years of Zen: https://40yearsofzen.com
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
  • The Human Upgrade: Biohacking for Longevity & Performance

    Putin Longevity, Pancreatic Cancer Cure, AI Therapy, GLP-1 Breast Cancer... : 1479

    2026-06-05 | 10 min.
    Pancreatic Cancer Halted by Virus Injection
    Researchers injected an engineered virus directly into pancreatic tumors in three patients — the virus replicated inside malignant cells, triggered an immune response, and stopped tumor growth and spread at an intentionally low early dose. Host Dave Asprey breaks down why oncolytic viruses can do what chemotherapy can't, how the tumor's dense biological wall becomes less of an advantage when a virus can replicate inside it directly, and why a measurable response at a safety dose is the kind of early signal that changes how he's watching this field.
    Sources:
    https://www.newscientist.com


    AI Chatbots and Teen Mental Health
    A new survey shows roughly one in five adolescents and young adults are now going to AI chatbots when they feel sad, anxious, nervous, or stressed, with usage heaviest in the 18–21 range. Host Dave Asprey explains why general-purpose language models designed to be engaging are dangerous as a substitute for real mental health support, why false reassurance from a chatbot may make the pipeline to real care harder to reach, and why this is a health systems story masquerading as a tech adoption story — and what parents need to do about it.
    Sources:
    https://www.nbcnews.com



    GLP-1 Drugs Cut Breast Cancer Risk
    Penn Medicine published a retrospective analysis of over 111,000 women finding GLP-1 exposure associated with about 35% lower odds of breast cancer in the full cohort and around 30% lower in a matched comparison group. Host Dave Asprey breaks down why this isn't just a weight loss story — it's a metabolic dysfunction story — explains the insulin resistance, inflammation, and hormonal environment mechanisms that may be driving the signal, and makes the case that this finding should be reshaping how oncologists and OBGYNs think about high-risk patients right now.
    Sources:
    https://www.pennmedicine.org


    Putin's $26 Billion Longevity Program
    The Wall Street Journal reports that Russia has made anti-aging research a Kremlin-level national priority through a $26 billion program including gene therapy, organ bioprinting, and xenotransplantation, led by Putin's daughter Maria Vorontsova and physicist Mikhail Kovalchuk. Host Dave Asprey breaks down what's geopolitical theater, what's legitimately frontier science, and why the real question is whether any findings will make it out to the broader research community or get locked inside a state program.
    Sources:
    https://www.wsj.com https://www.france24.com


    Sauna vs. Cold Plunge
    A landmark Finnish study tracked over 2,300 men for nearly 21 years and found increasing sauna frequency associated with dramatically lower cardiovascular and all-cause mortality — strongest at four or more sessions per week. Host Dave Asprey settles the debate with the actual data, explains what heat shock proteins and cold shock proteins actually are and why the evidence base behind them is nowhere near equivalent, and calls out the wellness marketing presenting early-stage mouse model research as the cold water equivalent of two decades of human mortality outcomes.
    Sources:
    https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2521522


    This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on cancer treatment breakthroughs, adolescent mental health and AI, metabolic drivers of disease, geopolitical longevity science, and the real evidence behind popular recovery modalities. Host Dave Asprey connects emerging clinical research, objective epidemiological data, and real-world optimization protocols into actionable frameworks for extending healthspan, sharpening performance, and staying ahead of the science.


    New episodes every Tuesday, Thursday, Friday, and Sunday.


    Keywords: oncolytic virus pancreatic cancer, engineered virus tumor treatment, AI chatbot teen mental health, adolescent AI emotional support, GLP-1 breast cancer risk, semaglutide cancer prevention, metabolic dysfunction root cause disease, Putin longevity program Russia, New Health Preservation Technologies, anti-aging biotech geopolitics, sauna longevity mortality data, cold plunge cold shock proteins, RBM3 heat shock proteins, sauna vs cold plunge evidence, biohacking news 2026, longevity research, Dave Asprey, The Human Upgrade


    Thank you to our sponsors!
    - Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today
    - Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade.
    - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE


    Resources:
    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
    • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/
    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
    • Danger Coffee: https://dangercoffee.com/discount/dave15
    • My Daily Supplements: SuppGrade Labs (15% Off)
    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
    • Dave Asprey’s BEYOND Conference: https://beyondconference.com
    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
    • Upgrade Labs: https://upgradelabs.com


    Timestamps:
    00:00 – Intro
    00:42 – Pancreatic Cancer Halted by Virus Injection
    01:44 – Teens & AI Therapy Chatbots
    03:13 – GLP-1 Drugs Cut Breast Cancer Risk
    04:30 – Russia's $26B Longevity Program
    06:18 – Sauna vs. Cold Plunge
    09:10 – Closing
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Om The Human Upgrade: Biohacking for Longevity & Performance
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
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