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The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey
The Human Upgrade: Biohacking for Longevity & Performance
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  • The Human Upgrade: Biohacking for Longevity & Performance

    Jordan Harbinger: Fight-or-Flight, Two Kidnappings, and the Wallet Ruining Your Spine : 1499

    2026-07-10 | 1 h 8 min.
    Nervous System Hacking, Willpower vs Habit Systems, Calendar Time Blocking, and the Wallet Posture Fix Damaging Your Spine

    Most people think surviving a life-threatening situation comes down to luck. Jordan Harbinger did it twice, and what got him out wasn't luck, it was a nervous system he had trained to override panic. This episode breaks down what actually happens in your body during a real fight-or-flight response, and how those same tools power his approach to human performance and hacking the excuses that keep most people stuck.

    Host Dave Asprey sits down with Jordan Harbinger, founder of The Art of Charm, one of the top podcasts in the world on charisma, negotiation, and relationship building. Jordan built his expertise the hard way, surviving two real kidnapping attempts using the same psychological principles he now teaches to entrepreneurs and high performers. That firsthand experience under extreme pressure is exactly what makes his insight into stress, willpower, and behavior change worth trusting.

    Jordan and Dave dig into what your nervous system does under real threat, why adrenaline hijacks rational thought, and how to build resilience that holds up when it matters most. They unpack why willpower fails as a long-term strategy, and why building smarter systems, not more discipline, is the real key to lasting change. Jordan breaks down his calendar-based productivity method, explains how sleep optimization and chronotype shape daily performance, and reveals a bizarre, physical habit quietly wrecking most people's spine and posture without them realizing it.

    This is essential listening for anyone serious about biohacking, human performance, hacking the nervous system, brain optimization, neuroplasticity, and longevity, and building resilience that performs under real pressure, not just in theory.

    You'll Learn:
    How Jordan Harbinger used psychology to talk his way out of two real kidnapping attempts
    What actually happens in your nervous system during a fight-or-flight response
    Why willpower fails as a long-term strategy and what to build instead
    How a calendar-based system eliminates decision fatigue and boosts daily performance
    How sleep optimization and chronotype affect brain function and productivity
    Why your wallet might be quietly damaging your spine and posture
    How to rewire ingrained habits and reactions through neuroplasticity and awareness

    Thank you to our sponsors!
    - PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off.
    - EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.
    - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

    Keywords: fight-or-flight response, nervous system regulation, adrenaline and cortisol, stress physiology, psychological resilience, kidnapping survival, Jordan Harbinger, The Art of Charm, willpower vs systems, habit change, decision fatigue, calendar time blocking, productivity systems, chronotype, sleep optimization, posture and spine health, nervous system hacking, neuroplasticity, self-deception and excuses, high performance psychology, biohacking, human performance

    Resources:
    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
    • Danger Coffee: https://dangercoffee.com/discount/dave15?
    • My Daily Supplements: SuppGrade Labs (15% Off)
    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
    • Dave Asprey’s BEYOND Conference: https://beyondconference.com
    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
    • Upgrade Labs: https://upgradelabs.com

    Timestamps:
    00:00 – Trailer
    00:58 – Guest Introduction
    02:33 – First Kidnapping Story
    06:54 – Second Kidnapping Story
    14:25 – Escape & Evasion Training
    23:26 – New Year's Resolutions
    38:30 – Calendar Productivity System
    51:45 – Wallet Audits & Minimalism
    55:23 – Talking Your Way Out of Tickets
    1:00:42 – Final Advice: Relationships
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
  • The Human Upgrade: Biohacking for Longevity & Performance

    The Foods, Drinks, and Daily Habits Wrecking Your Brain (Surprising!) | David Perlmutter : 1498

    2026-07-09 | 53 min.
    Neurologist Dr. David Perlmutter Explains Brain Inflammation and Alzheimer's Risk

    Your brain has its own immune system, and when it turns against you, it becomes the hidden driver behind Alzheimer's, Parkinson's, depression, and even long COVID. This episode hands you the science to recognize it early and reverse it.


    Get Dr. Perlmutter’s new book Brain Defenders: https://drperlmutter.com/books/brain-defenders/


    Host Dave Asprey sits down with Dr. David Perlmutter, a board-certified neurologist and six-time New York Times bestselling author whose work sits at the intersection of neurology, nutrition, and brain health. He is a Fellow of the American College of Nutrition, serves on its Board of Directors, and sits on the Editorial Board of the Journal of Alzheimer's Disease. His books, including the number one bestseller Grain Brain, span 32 languages and have sold over a million copies, and his upcoming release, Brain Defenders, explores the pivotal role of microglia, the brain's immune cells, in protecting, repairing, and reprogramming the brain for lifelong resilience.


    Dave and Dr. Perlmutter break down how microglia, the brain's resident immune cells, shift from a supportive state into a destructive one called M1, and why this shift, not amyloid plaque, may be the real driver of Alzheimer's, Parkinson's, and other neurodegenerative conditions. They dig into why the leading amyloid-clearing drugs fail to improve cognition, what a landmark JAMA study revealed about reversing cognitive decline through lifestyle intervention alone, and why a single daily serving of ultra-processed food raised Alzheimer's risk by 13 percent in a 12.7 year study. They also cover new research on GLP-1 drugs and brain inflammation, the surprising role of gum disease and oral bacteria in dementia risk, and why 40 hertz light therapy is emerging as a low-cost tool for clearing brain plaque and calming neuroinflammation.


    You'll Learn:
    Why the shift from supportive to destructive brain immune cells may be the true root cause of Alzheimer's and Parkinson's
    Why leading Alzheimer's drugs fail to improve cognition, and what the original research behind the amyloid hypothesis actually showed
    How one daily serving of ultra-processed food raises Alzheimer's risk, and what a landmark lifestyle intervention study found instead
    Whether GLP-1 drugs help or harm brain inflammation, based on new Parkinson's and Alzheimer's trial data
    How gum disease and oral bacteria are linked to dementia, and simple daily habits that reduce that risk
    Why 40 hertz light therapy is emerging as a tool to clear brain plaque and calm neuroinflammation
    How ketones, DHA, and metabolic health protect the brain after head injury


    Thank you to our sponsors!
    - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com.
    - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.
    - Pique | Head over to Piquelife.com/Dave to get 20% off your order. That's P-I-Q-U-E life dot com slash DAVE
    - PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off.


    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


    Keywords: microglia, brain inflammation, Alzheimer's prevention, Parkinson's disease, amyloid hypothesis, neurodegeneration, GLP-1 drugs, semaglutide, ultra-processed food, gum disease and dementia, oral microbiome, 40 hertz light therapy, ketones, DHA, mitochondria, brain fog, long COVID, David Perlmutter, Brain Defenders, Grain Brain, functional medicine, biohacking, longevity, neuroplasticity


    Resources:
    • Get Dr. Perlmutter’s New Book Brain Defenders: https://drperlmutter.com/books/brain-defenders/
    • Learn More About Dr. Perlmutter’s Work At: https://drperlmutter.com/
    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
    • Danger Coffee: https://dangercoffee.com/discount/dave15?
    • My Daily Supplements: SuppGrade Labs (15% Off)
    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
    • Dave Asprey’s BEYOND Conference: https://beyondconference.com
    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
    • Upgrade Labs: https://upgradelabs.com


    Timestamps:
    00:00 – Trailer
    00:40 – Intro
    02:38 – Ultra-Processed Foods
    06:34 – Are Carbs Bad?
    08:48 – Alcohol & Brain Health
    12:28 – Microglia & Inflammation
    24:37 – Head Injury & Recovery
    29:27 – Oral Bacteria & Dementia
    34:08 – GLP-1s & Brain Inflammation
    40:20 – 40 Hertz Light Therapy
    48:35 – Air Pollution vs. Lead
    50:27 – David's Closing Truth
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
  • The Human Upgrade: Biohacking for Longevity & Performance

    The 1910 Secret: How Light Turns Water Into Medicine | Brain Richards : 1497

    2026-07-07 | 1 h
    Near-Infrared Light Therapy & EMF Shielding with SaunaSpace Founder Brian Richards

    Your mitochondria are starving for a nutrient you've probably never tracked, and it's not a vitamin or a macro. This episode reveals how a forgotten 1910 therapy uses light to physically restructure water inside your cells, unlocking a mechanism for healing, detox, and mitochondria repair that most of biohacking has completely overlooked.

    Go to https://sauna.space/ and use code ‘Dave’ for a 15% discount!

    Host Dave Asprey sits down with Brian Richards, founder of SaunaSpace and a leading voice in incandescent light therapy and infrared sauna engineering. With a background in chemistry and organic synthesis, Brian spent over a decade building a science-backed alternative to LED-based light therapy rooted in full-spectrum incandescent light and deep radiant heat. After healing his own insomnia, adrenal fatigue, and brain fog through light and heat exposure, he developed the FireLight Spectrum, a technology engineered to restore what modern lighting strips away.

    Dave and Brian trace incandescent light therapy back to Dr. John Harvey Kellogg's 1910 book on light therapeutics, and explain why the same institutional forces that suppressed chiropractic care and natural medicine buried this practice for over a century. They break down how near-infrared light penetrates the body to charge water into a more bioavailable state, boost glutathione and melatonin production, and repolarize cellular voltage for better metabolism and longevity. The conversation also covers why blue light from LEDs devastates hormones, testosterone, and fertility, how EMF exposure silently drains human performance, and why grounding and Faraday shielding matter more than most supplements on the market.

    You'll Learn:
    Why near-infrared light functions as an essential nutrient your body cannot make without it
    How light physically restructures water to improve mitochondria function and cellular energy
    The suppressed history of Dr. Kellogg's incandescent light therapy and why it disappeared
    How blue light exposure crashes testosterone and disrupts fertility and hormone regulation
    Why EMF shielding and grounding are critical, overlooked tools for longevity and recovery
    How to use infrared light like a daily supplement instead of an occasional treatment
    Why carnivore-adjacent, nutrient-dense eating pairs naturally with light and heat therapy

    Thank you to our sponsors!
    - ELITE Performance Coaching | If you’d like to discover where you may be addicted to struggle, allergic to success, and what may be standing between you and your next breakthrough, visit FastestChange.com
    - Longevity Farms | Go to getlongevityfarms.shop. Use code DAVE for 20% off your next order.
    - Calroy | Go to calroy.com/dave for the clinical research, your discount, and a 45-day money-back guarantee.
    - PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off.

    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

    Keywords: Brian Richards, SaunaSpace, incandescent light therapy, near-infrared light, FireLight Spectrum, Dr. John Harvey Kellogg, Light Therapeutics, exclusion zone water, Gerald Pollack, EMF shielding, Faraday cage, grounding mat, earthing, redox potential, mitochondrial energy, glutathione, melatonin, blue light toxicity, circadian biology, red light therapy, heat shock proteins, vitamin D, sun callus, Danger Coffee, Flexner Report, testosterone, biophotons

    Resources:
    • Go to https://sauna.space/ and use code ‘Dave’ for a 15% discount!
    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
    • Danger Coffee: https://dangercoffee.com/discount/dave15?
    • My Daily Supplements: SuppGrade Labs (15% Off)
    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
    • Dave Asprey’s BEYOND Conference: https://beyondconference.com
    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
    • Upgrade Labs: https://upgradelabs.com

    Timestamps:
    00:00 – Trailer
    00:46 – Meet Brian Richards
    03:17 – Kellogg's Light Bath History
    09:04 – Persecuted Light Pioneers
    12:47 – Near-Infrared Science
    16:07 – Blue Light Damage
    19:26 – Sunscreen Myths
    23:52 – Antidote & Melatonin
    33:24 – Exclusion Zone Water
    37:52 – Heart as a Vortex
    41:47 – Fireplace & Infrared Deficiency
    46:15 – FireLight Bulb Design
    51:52 – EMF Shielding
    55:16 – Faraday Cage & Grounding
    1:05:51 – Sauna.Space Discount
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
  • The Human Upgrade: Biohacking for Longevity & Performance

    I Tried EVERY Legal Focus Drug, Here’s What Actually Works : 1496

    2026-07-05 | 16 min.
    Try Danger Creatine: https://dangercoffee.com/products/danger-creatine
    Try TrueDark glasses: https://truedark.com
    Try Danger Coffee: https://dangercoffee.com/
    Try Suppgrade Labs: https://shopsuppgradelabs.com/

    I have spent twenty years and millions of dollars testing every legal focus drug I could get my hands on. In this video, I break down which compounds actually work, which ones are a waste of money, and the exact stack that delivers hours of clean focus without the afternoon crash.

    The shift is simple: focus isn't a willpower problem. It's an energy production problem inside your brain. Once you fuel it at the cellular level, deep focus stops being a struggle and becomes the default state.

    Thank you to our sponsors!
    ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.
    EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.
    iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

    Timestamps:
    0:00 – The Longevity Switch
    0:47 – Why Mitochondria Matter
    2:28 – What Mitophagy Is
    2:46 – How Mitophagy Works
    4:18 – What Shuts It Off
    8:54 – The Damage Compounds
    9:22 – How to Turn It Back On
    10:31 – Signal 1: Fasting
    11:48 – Signal 2: Exercise (REHIT)
    12:30 – Signal 3: Cold Exposure
    13:22 – Signal 4: NAD+
    14:29 – Signal 5: Urolithin A and Spermidine

    Connect with Dave Asprey!

    Website: https://daveasprey.com
    TikTok: https://www.tiktok.com/@daveaspreyofficial
    Instagram: https://www.instagram.com/dave.asprey/
    Facebook: https://www.facebook.com/Daveaspreyofficial/
    X: https://x.com/daveasprey
    YouTube: https://www.youtube.com/c/daveaspreybpr

    The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

    Danger Coffee: https://dangercoffee.com/DAVE15
    Dave Asprey’s BEYOND Conference: https://beyondconference.com/
    Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
    Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15
    Upgrade Labs: https://upgradelabs.com
    40 Years of Zen: https://40yearsofzen.com
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
  • The Human Upgrade: Biohacking for Longevity & Performance

    Organic Produce, Exercise vs Income, Cat Parasite, Thorne, Loss of Taste, and more... : 1495

    2026-07-03 | 10 min.
    GLP-1 Side Effects, Gut Microbiome & Brain Health, Toxoplasmosis Risks, and the Dirty Dozen Explained

    Plasma Acetate Emerges As Key Gut-Brain Messenger In Older Adults
    A study published in Nature Communications examined how gut bacteria relate to plasma acetic acid, a short-chain fatty acid produced when gut microbes ferment fiber, and found that higher acetate levels tracked with lower triglycerides, higher HDL cholesterol, lower body fat, larger thalamic brain volume, and stronger performance on judgment-related cognitive tasks. Mediation analysis showed acetate acts as a direct link between specific gut bacteria, including Oscillibacter and Coprococcus, and these health outcomes. Host Dave Asprey breaks down why this elevates fiber fermentation, not fermented beverages, as the real lever for gut-brain health, and separates the evidence-backed mechanism from the kombucha-as-shortcut assumption.
    Source:
    https://www.nature.com/articles/s43856-026-01566-x
    ~~

    GLP-1 Drugs Linked To Sharp Rise In Smell And Taste Disturbances
    A JAMA Otolaryngology cohort study tracking over 438,000 GLP-1 users against matched controls found a 48% higher risk of new smell or taste disturbances over two years, with smell disturbances up 81% and taste disturbances up 52%. Diagnoses included anosmia, parosmia, and parageusia, with researchers pointing to GLP-1 receptor activity in the olfactory bulb and other chemosensory pathways as a possible mechanism. Host Dave Asprey unpacks why this signal got buried under muscle loss and gut motility headlines, and what it means for anyone currently on or considering GLP-1 therapy.
    Sources:
    https://jamanetwork.com/journals/jamaotolaryngology/article-abstract/2850571
    https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/10.1001/jamaoto.2026.1498
    https://trial.medpath.com/news/glp-1-receptor-agonists-linked-to-increased-risk-of-smell-and-taste-disturbances-study-finds
    ~~

    Scientists Push For Toxoplasmosis To Be Recognized As A Neglected Tropical Disease
    A viewpoint paper in PLOS Neglected Tropical Diseases argues that toxoplasmosis, a parasitic infection carried by roughly one in three people globally, deserves WHO neglected tropical disease status given its outsized impact on vision and maternal-child health. Ocular toxoplasmosis is the most common intra-ocular infection worldwide, and an estimated 190,000 babies are born with congenital toxoplasmosis each year, concentrated in low-resource regions. Despite the scale, there is still no vaccine and no standard global treatment protocol. Host Dave Asprey explains why common, quiet health threats get chronically underfunded compared to dramatic outbreaks, and what pregnant listeners specifically should know about exposure risk.
    Source:
    https://www.sciencealert.com/parasite-affecting-1-in-3-people-is-a-serious-risk-to-human-health-scientists-warn
    ~~

    Yale-Oxford Data Shows Exercise May Boost Mental Health More Than A Raise
    An analysis of CDC survey data from over 1.2 million U.S. adults found that people who exercise regularly report 1.5 to 2 fewer poor mental health days per month than non-exercisers, a benefit comparable to earning about $25,000 more per year. The data also revealed an inverted-U relationship, with optimal benefits at three to five sessions a week and diminishing or reversed returns at extreme volumes. Host Dave Asprey breaks down why moderate, consistent movement outperforms income as a mental health lever, and why overtraining carries its own psychological cost.
    Sources:
    https://www.weforum.org/stories/2019/04/exercise-officially-makes-you-happier-than-money-according-to-yale-and-oxford-research/
    https://medicine.yale.edu/news-article/exercise-linked-to-improved-mental-health-but-more-may-not-always-be-better/
    ~~

    Unilever Reportedly Exploring $4 Billion Bid For Supplement Brand Thorne
    Unilever is said to be evaluating a bid for Thorne, the clinical-grade supplement brand currently owned by private equity firm L Catterton, in a deal that could value the company at up to $4 billion, with Haleon also reportedly circling. The move reflects a broader trend of major consumer-health conglomerates acquiring practitioner-trusted, lab-forward wellness brands. Host Dave Asprey weighs in on what happens to product quality and innovation when founder-led, science-first supplement companies get absorbed into shareholder-first parent corporations.
    Source:
    https://www.reuters.com/business/unilever-explores-bid-supplements-maker-thorne-ft-reports-2026-06-26/
    ~~

    New Research Maps How Your Microbiome Processes Plant Compounds, And What It Means For Your Produce Aisle Choices
    Researchers mapped 775 phytonutrients from over 1,100 edible plants against nearly 2,000 gut bacterial enzymes across thousands of human microbiomes, linking that enzyme activity to outcomes in IBD, colorectal cancer, and fatty liver disease. Individuals varied widely in how many of these compounds their gut could actually process, and in mouse studies, strawberries reduced colitis activity only in mice with an intact microbiome. Host Dave Asprey explains why the plant itself isn't the active ingredient, your bacteria are, and connects the findings to this year's Environmental Working Group Dirty Dozen and Clean Fifteen lists to help listeners decide where organic actually matters.
    Sources:
    https://pmc.ncbi.nlm.nih.gov/articles/PMC12768975/
    https://www.eurekalert.org/news-releases/1108351
    https://www.nature.com/articles/s41564-025-02197-z
    ~~

    This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want mechanism-level insights into the gut-brain axis, an underreported GLP-1 side effect, a global parasite hiding in plain sight, the real ROI of exercise on mental health, consolidation in the supplement industry, and how your microbiome determines what your produce actually does for you. Host Dave Asprey connects clinical research, large cohort studies, mechanistic biology, and industry news into practical frameworks for improving gut health, brain performance, and long-term resilience.

    New episodes every Tuesday, Thursday, Friday, and Sunday.

    Keywords: plasma acetate gut brain axis, short chain fatty acids, gut microbiome cognition, GLP-1 smell taste disturbances, anosmia parosmia GLP-1, semaglutide side effects, toxoplasmosis neglected tropical disease, Toxoplasma gondii health risks, congenital toxoplasmosis, exercise mental health study, exercise versus income happiness, overtraining mental health, Unilever Thorne acquisition, supplement industry consolidation, phytonutrient gut bacteria enzymes, polyphenol metabolism microbiome, Dirty Dozen Clean Fifteen 2026, pesticide residue produce, biohacking news 2026, Dave Asprey, The Human Upgrade

    Thank you to our sponsors!
    - PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off.
    - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.
    - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

    Resources:
    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
    • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/
    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
    • Danger Coffee: https://dangercoffee.com/discount/dave15
    • My Daily Supplements: SuppGrade Labs (15% Off)
    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
    • Dave Asprey’s BEYOND Conference: https://beyondconference.com
    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
    • Upgrade Labs: https://upgradelabs.com

    Timestamps:
    00:00 – Story #1: Acetate & Gut-Brain Health
    01:57 – Story #2: GLP-1s & Smell/Taste Loss
    03:22 – Story #3: Toxoplasmosis Risks
    04:33 – Story #4: Exercise vs Income
    05:53 – Story #5: Phytonutrients & Gut Enzymes
    07:45 – Dirty Dozen & Clean Fifteen
    08:46 – Story #6: Thorne Acquisition
    09:49 – Takeaway
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Om The Human Upgrade: Biohacking for Longevity & Performance
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
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