The Human Upgrade: Biohacking for Longevity & Performance

Fix Leaky Gut, Boost Testosterone & Slash Endotoxins with Spore-Based Probiotics | Kiran Krishnan

Your bad gut bacteria might be the reason your testosterone, your immune system, and even your sperm count are struggling, and most probiotics never survive long enough to fix it. This episode reveals which strains actually make it through your stomach acid alive, and what happens once they do.

Go To JustThriveHealth.com/asprey for a free 90 day supply of bitters with your next subscription.

Host Dave Asprey sits down with research microbiologist Kiran Krishnan, co-founder of Microbiome Labs, the leading microbiome therapeutics brand among healthcare professionals. He has published multiple peer-reviewed studies, holds global patents, and has spent 20 years building companies focused on the science of the microbiome. His work centers on spore-based probiotics, the rare strains proven to survive the stomach's brutal acidity and actually rebuild the gut from the inside out.

Kiran and Dave break down why 98 percent of conventional probiotics die before they ever reach your gut, and why spore-forming bacteria are different. They dig into the "gelding effect," the well-documented pathway where endotoxins from bad gut bacteria shut down testosterone production and drive up cortisol, and how fixing your microbiome can reverse it. They cover the connection between endotoxemia and nearly every major marker of aging, metabolism, and inflammation, why butyrate acts like a natural GLP-1 for fat loss, how Akkermansia can upregulate mitochondria and improve blood sugar control, and the surprising role vitamin K2 plays in bone density and functional medicine. This is biohacking at the cellular level, using ancient biology, fasting-adjacent metabolic pathways, and precision supplementation to optimize human performance from the gut up.

You'll Learn:
Why 98 percent of probiotics die in your stomach before they ever work
What the "gelding effect" is and how gut bacteria can shut down testosterone
How endotoxins drive inflammation, cortisol, and accelerated aging
Why butyrate functions like a natural, low-cost alternative to GLP-1 drugs
How Akkermansia improves mitochondrial function and blood sugar control
The overlooked link between your microbiome and vitamin K2 production
Why spore-based probiotics can survive gastric acid when most others cannot
How 90 days of gut repair can measurably reduce circulating endotoxins

Keywords: best probiotics that survive stomach acid, spore based probiotics benefits, gelding effect testosterone, endotoxins and testosterone, how to lower endotoxins, LPS gut bacteria, Akkermansia GLP-1 natural, gut bacteria and belly fat, vitamin K2 bone density, Kiran Krishnan microbiologist, Just Thrive probiotic, leaky gut symptoms, microbiome and testosterone, fecal transplant benefits, Dave Asprey, biohacking, longevity

Resources:
• Go To JustThriveHealth.com/asprey for a free 90 day supply of bitters with your next subscription
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Timestamps:
00:00 – Trailer
00:38 – Kiran Intro
02:01 – Stomach Acid & Probiotics
05:25 – Fauci & Spore Bacteria
13:58 – Losing Gut Diversity
19:01 – How Butyrate Is Made
22:11 – Dave's Personal Stack
24:00 – Quorum Sensing
31:26 – Endotoxins Explained
37:13 – Charcoal & Binders
39:41 – SIBO & Gut Bacteria
45:03 – Discovering Vitamin K2
49:33 – Gelding Effect & Testosterone
54:51 – Akkermansia & Weight Loss
01:02:17 – Role of Bitters
01:04:47 – Just Thrive Gift
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Visceral fat, subcutaneous fat, Prenuvo MRI scans, and the truth about belly fat

Your gut and your face are telling on you. This episode reveals why the fat under your skin might be protecting you while the fat around your organs is quietly wrecking your metabolism, heart, and longevity, and exactly what to do about the difference.

Get $300 off your next Prenuvo MRI scan: https://prenuvo.com/?discount=Dave

Host Dave Asprey sits down with Dr. Sean O'Mara, a former undercover narcotics agent, criminal prosecutor, emergency medicine physician, and retired U.S. Army Colonel who assisted the White House and Senior Executive Service, treating Vice President Dick Cheney, former President Bill Clinton, and Secretary of State Colin Powell. Today he's recognized as the world's most experienced physician in eliminating visceral fat and epicardial adipose tissue (EAT), the inflammatory fat now linked to nearly every major chronic disease and accelerated aging. He founded Influence Medicine, a specialty built around helping senators, heads of state, and top executives optimize their biology so they can perform and lead at the highest level.

Dave and Dr. O'Mara break down the real difference between visceral fat and subcutaneous fat, why a visible six-pack might signal hidden disease, and how MRI scans reveal what your mirror never will. They dig into the biohacking strategies that actually shift your body composition: fasting protocols that build beneficial fat instead of burning it away, microbiome optimization for fat metabolism, and the supplements and functional medicine tools Dr. O'Mara uses with his highest-performing clients. They also cover the gut-hormone connection driving modern metabolic dysfunction, why political leaders are quietly getting scanned, and what your face reveals about your visceral fat levels before you ever step on a scale.

You'll Learn:
The real difference between visceral fat, subcutaneous fat, and why one protects you while the other kills you
Why a six-pack might be hiding disease your MRI would catch
How a 72-hour fasting protocol can build the good kind of fat through adiponectin signaling
What your face reveals about your visceral fat and longevity risk
The gut-hormone connection driving testosterone, metabolism, and inflammation
Why senators and world leaders are getting scanned for hidden fat
How microbiome health, fasting, and functional medicine work together for fat loss and longevity

Thank you to our sponsors!
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Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: visceral fat vs subcutaneous fat, how to reduce visceral fat, best fat for longevity, MRI body scan benefits, Prenuvo full body scan, what is epicardial fat, skinny fat TOFI explained, why is my six pack unhealthy, 72 hour fasting benefits, fasting and testosterone, how to build subcutaneous fat, biohacking visceral fat, Sean O'Mara doctor, influence medicine, fecal microbiota transplant benefits, gut microbiome and fat loss, Dave Asprey, biohacking, longevity

Resources:
• Learn More About Dr. O’Mara’s Work At: https://drseanomara.com/
• Get $300 Off Your Next Prenuvo MRI Scan: https://prenuvo.com/?discount=Dave
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15?
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com


Timestamps:
00:00 – Trailer
00:58 – Intro
02:38 – Fat Type Basics
04:19 – Reviewing Dave's Scan
08:04 – Good Fat vs. Bad Fat
16:49 – Fertility & Pregnancy
19:47 – Personality & Health
21:51 – Wealth & Health Neglect
30:32 – Insurance Incentives
39:29 – Microbiome & Disease
40:41 – FDA & Fecal Transplants
42:57 – Viome & Biomarker Data
45:40 – Skinny Fat & Appearance
49:44 – Building Subcutaneous Fat
52:57 – Fasting Protocol
58:37 – Closing
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Most people think biohacking is only for billionaires with access to expensive machines, private clinics, and million-dollar anti-aging protocols. But the truth is, some of the most powerful upgrades in your biology start with the basic signals your body receives every single day.

In this video, Dave Asprey breaks down how to start biohacking with around $200 by focusing on the foundations that control your sleep, energy, focus, and cellular repair. These are the simple changes that can create a massive difference before you ever spend money on advanced technology.

If you’ve ever wanted to feel sharper, recover better, sleep deeper, and support your body’s natural repair systems without wasting money on random gadgets, this video shows you where to start.

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I have spent twenty years and millions of dollars testing every legal focus drug I could get my hands on. In this video, I break down which compounds actually work, which ones are a waste of money, and the exact stack that delivers hours of clean focus without the afternoon crash.

The shift is simple: focus isn't a willpower problem. It's an energy production problem inside your brain. Once you fuel it at the cellular level, deep focus stops being a struggle and becomes the default state.

Thank you to our sponsors!
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00:00 – Trailer
00:53 – Sleep Environment Matters
03:44 – Red Light Bulbs
04:50 – Blackout Curtains
05:16 – Light-Blocking Glasses
07:16 – Morning Supplement Stack
07:41 – Creatine for the Brain
11:48 – MCT Oil Fuel
13:06 – Cellular Cleanup (Autophagy)
15:12 – Magnesium for Sleep
16:56 – Full Stack Recap
18:26 – Biohacking Is Accessibl

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Shawn Stevenson On The Science of Family Meals, Oxytocin, and Longevity

Your dinner table might be the most overlooked biohack in your house. This episode reveals the exact minimum dose of family meals that lowers a child's risk of obesity, the hormone your body releases every time you eat with people you love, and why teaching your kids to cook may protect their metabolism for life.

Host Dave Asprey sits down with Shawn Stevenson, founder of The Model Health Show and author of the bestselling Eat Smarter Family Cookbook series. Shawn spent over two decades studying nutritional science and functional medicine after recovering from advanced degenerative disc disease at age 20, and he has become one of the most trusted voices in health media for turning peer-reviewed research into real-world family habits.

Shawn and Dave break down the science of community eating, including new research on oxytocin, nervous system regulation, and metabolism that shows why sitting down together beats eating alone every time. They cover the four biological drives running your behavior, the connection between family culture and longevity, and how simple shifts like humming, breathwork, and intentional meals can support brain optimization and anti-aging at a cellular level. This conversation also dives into the five love languages hidden inside food, a bio-photon DNA experiment that reframes how energy moves between people, and the exact number of meals per week that changes a child's health trajectory.

You'll Learn:
The minimum effective dose of family meals per week that lowers childhood obesity and disordered eating
How oxytocin and a regulated nervous system change what happens at the dinner table
Why teaching kids to cook protects their metabolism and prevents dependence on ultra-processed food
How the five love languages show up in how you cook, serve, and share food
The bio-photon DNA experiment that shows how human energy fields affect the world around you
Why culture is something your family creates, not just something you inherit
How humming and breathwork practices can shift your nervous system and even change your voice

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.

Keywords: Shawn Stevenson, Dave Asprey, The Human Upgrade, biohacking, family dinner, family meals, community eating, longevity, functional medicine, oxytocin, nervous system regulation, childhood obesity, teaching kids to cook, five love languages, Model Health Show, Eat Smarter Family Cookbook, brain optimization, anti-aging, metabolism, nutrition science, mental health, family culture, healthy habits, minimum effective dose, human performance

Thank you to our sponsors!
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Resources:
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/davetube
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com
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Why Oral and IV Glutathione Never Actually Reach Your Cells (The Delivery Breakthrough Changing Everything)

Most of the supplements you're taking aren't failing you, they're failing to ever reach the cells that need them, and almost nobody selling them wants you to know that. This episode hands you the delivery breakthrough that actually gets it there.

Use code DAVE for a discount at aurowellness.com/dave

Host Dave Asprey sits down with Dr. Nayan Patel, a pharmacist, researcher, and founder of Auro Wellness, whose work centers on solving one of biohacking's most stubborn problems: getting nutrients past the bloodstream and into the cells that actually need them. He holds 14 patents in delivery technology, partners in the high-end longevity clinic Unlimited Life, and has spent over two decades studying glutathione, the master antioxidant his own research helped bring into modern biohacking.

Dave and Dr. Patel break down a 2011 University of Texas study showing that oral and liposomal glutathione are completely broken down into raw amino acids before absorption, meaning none of it reaches the bloodstream as glutathione, a pattern that holds true even for IV administration. They dig into new brain-imaging research showing topical glutathione crossing into neural tissue within 20 minutes, why senescent "zombie cells" may be directly tied to glutathione shortfalls, and why NAD, despite its reputation as the ultimate longevity molecule, is actually dependent on glutathione to do its job. They also cover the real purity ceiling on GHK-copper peptides, safe upper limits for glycine and NAC before they start working against you, a topical alcohol protocol that clears acetaldehyde without triggering a breathalyzer, and why oxidative stress from GLP-1 use is quietly driving one of the drug class's least-discussed side effects.

You'll Learn:
Why oral, liposomal, and even IV glutathione never actually reach your cells intact, and what a 2011 UT study proved about it
How topical glutathione was shown to cross into brain tissue within 20 minutes, and what that means for neurological aging
Why senescent "zombie cells" may be directly linked to glutathione shortfalls, and how one longevity clinic reversed markers by 70% in a year
Why NAD isn't the "ultimate longevity drug" it's marketed as, and its actual dependent relationship with glutathione
The real purity ceiling on GHK-copper peptides, and why 73% is currently the best available anywhere
Safe upper limits for glycine and NAC, and the oxalate crystal and Parkinson's-like risks of overdoing either one
A topical alcohol protocol that clears acetaldehyde fast enough to beat a breathalyzer
Why GLP-1 drugs are quietly driving oxidative stress, and what most patients are missing to counter it


Thank you to our sponsors!
- PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off.
- OneSkin | Get 15% off OneSkin with the code DAVE at https://www.oneskin.co/DAVE #oneskinpod
- Caldera + Lab | A small habit with big results. Go to CalderaLab.com/DAVE and use code DAVE for 20% off your first order.
- Fatty15 is on a mission to support Healthy Aging for All, including all ages and stages of life. You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com and using code DAVE at checkout

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: glutathione, Nayan Patel, Ora Wellness, glutathione absorption, transdermal delivery, senescent cells, zombie cells, cellular aging, GHK-copper peptide, NAD, NAD supplements, NAC, glycine, GlyNAC, oxalate crystals, alcohol metabolism, acetaldehyde, GLP-1, semaglutide, oxidative stress, heavy metal detox, mercury toxicity, BPC-157, biohacking, longevity, functional medicine

Resources:
• Get A Discount On Auro Wellness Products - Use code DAVE: aurowellness.com/dave
• Learn More About Dr. Patel’s work at: http://aurowellness.com/dave
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/davetube
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
00:00 – Trailer
00:43 – Episode Intro
03:16 – Glutathione Basics
07:34 – Senescent Cells
11:07 – Cellular Delivery Science
14:20 – GlyNAC Precursors
21:37 – Amino Acid Ratios
25:18 – GHK Copper Peptide
28:41 – Purity & Manufacturing
31:34 – Glutathione vs. NAD
33:49 – Absorption Studies
37:51 – Heavy Metals & Toxins
42:35 – Alcohol & Glutathione
47:43 – Mortality & Reincarnation
49:54 – GLP-1s & Anhedonia
53:25 – Future of Peptides
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