You've probably heard of CRISPR, the revolutionary technology that allows us to edit the DNA in living organisms. Biochemist and 2023 Audacious Project grantee Jennifer Doudna earned the Nobel Prize for her groundbreaking work in this field -- and now she's here to tell us about its next world-changing advancement. She explains how her team at the Innovative Genomics Institute is pioneering a brand new field of science -- precision microbiome editing -- that uses CRISPR in an effort to solve seemingly insurmountable problems like asthma, Alzheimer's and climate change. (This ambitious idea is part of the Audacious Project, TED's initiative to inspire and fund global change.)

Ever think you'd hear Sandra Bullock, Britney Spears and Dolly Parton in one TED Talk? Here they are, courtesy of "Saturday Night Live" star Melissa Villaseñor. She shares the life lessons of a comedian -- complete with celebrity impressions -- and reminds us to embrace all of our voices, even if they're a little silly.

The word "sustainability" gets thrown around a lot these days. But what does it actually mean for humanity to be sustainable? Environmental data scientist Hannah Ritchie digs into the numbers behind human progress across centuries, unpacking why the conventional understanding of sustainability is misleading and showing how we can be the first generation of humans to actually achieve it.

Your favorite pair of jeans -- the ones you refuse to throw out -- are actually a part of a global climate solution, says fashion entrepreneur Josephine Philips. When you value your existing clothes instead of chasing the latest trends, you help reduce waste and protect our planet for generations to come. Learn more about the impacts of what you wear -- and the incredible power of repairing your clothes.

"AI can be a transformational tool in our fight against climate change," says Sims Witherspoon, a leader at the AI research lab Google DeepMind. Using wind power as her case study, she explains how powerful neural networks can help us better predict Earth's changing ecosystems and accelerate the breakthrough science needed to create a carbon-free energy supply.