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  • #240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?
    Dr. David Fajgenbaum, MD, MBA, MSc, is a pioneering physician-scientist, tenured professor at the Perelman School of Medicine at the University of Pennsylvania, and national bestselling author who transformed his personal battle with the rare, deadly Castleman disease into a global mission to accelerate cures for humanity's 12,000 known diseases. Diagnosed after losing his mother to cancer, Fajgenbaum endured five near-death experiences before using his medical training to identify sirolimus—a repurposed drug—as a life-saving treatment, achieving remission marking over a decade cancer-free as of 2025. A Georgetown University graduate with advanced degrees from Oxford and Wharton, he co-founded the Castleman Disease Collaborative Network (CDCN) and Every Cure, leveraging AI and drug repurposing to unlock hidden treatments, earning spots on TIME's 2025 TIME100 Health list and major media recognition for his "cure thyself" story. Through his book Chasing My Cure and speaking engagements, Fajgenbaum inspires hope, advocates for patient-driven research, and pushes for policy changes to speed up cures for rare diseases affecting millions worldwide. Shawn Ryan Show Sponsors: https://americanfinancing.net/srs NMLS 182334, nmlsconsumeraccess.org. APR for rates in the 5s start at 6.327% for well qualified borrowers. Call 866-781-8900, for details about credit costs and terms. https://bunkr.life – USE CODE SRS Go to https://bunkr.life/SRS and use code “SRS” to get 25% off your family plan. https://shawnlikesgold.com https://ROKA.com – USE CODE SRS https://simplisafe.com/srs https://USCCA.com/srs https://ziprecruiter.com/srs https://gemini.com/srs Sign up for the Gemini Credit Card: https://Gemini.com/SRS #GeminiCreditCard #CryptoRewards #Advertisement This video is sponsored by Gemini. All opinions expressed by the content creator are their own and not influenced or endorsed by Gemini. The Bitcoin Credit Card™ is a trademark of Gemini used in connection with the Gemini Credit Card®, which is issued by WebBank. For more information regarding fees, interest, and other cost information, see Rates & Fees: gemini.com/legal/cardholder-agreement. Some exclusions apply to instant rewards; these are deposited when the transaction posts. 4% back is available on up to $300 in spend per month for a year (then 1% on all other Gas, EV charging, and transit purchases that month). Spend cycle will refresh on the 1st of each calendar month. See Rewards Program Terms for details: gemini.com/legal/credit-card-rewards-agreement. Checking if you’re eligible will not impact your credit score. If you’re eligible and choose to proceed, a hard credit inquiry will be conducted that can impact your credit score. Eligibility does not guarantee approval. The appreciation of cardholder rewards reflects a subset of Gemini Cardholders from 10/08/2021 to 04/06/2025 who held Bitcoin rewards for at least one year. Individual results will vary based on spending, selected crypto, and market performance. Cryptocurrency is highly volatile and may result in gains or losses. This information is for general informational purposes only and does not constitute investment advice. Past performance is not indicative of future results. Consult with your tax or financial professional before investing. Dr. David Fajgenbaum Links: Website - https://davidfajgenbaum.com X - https://x.com/DavidFajgenbaum IG - https://www.instagram.com/dfajgenbaum LI - https://www.linkedin.com/in/davidfajgenbaum Every Cure - https://everycure.org Castleman Disease Collaborative Network - https://cdcn.org TED talk - go.ted.com/davidfajgenbaum TED YT - https://youtu.be/sb34MfJjurc Chasing My Cure (Amazon) - https://www.amazon.com/Chasing-My-Cure-Doctors-Action/dp/1524799637 Learn more about your ad choices. Visit podcastchoices.com/adchoices
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  • #239 Dan Driscoll - U.S. Secretary of the Army
    Daniel P. Driscoll is the 26th Secretary of the Army, sworn in on February 25th, 2025, following his nomination by President Donald J. Trump and confirmation by the United States Senate. As Secretary of the Army, he oversees operations, modernization, and resource allocation for nearly one million Active, Guard, and Reserve Soldiers and more than 265,000 Army Civilians. A former Army officer and business leader, Secretary Driscoll brings experience spanning military service, law, and the private sector. Secretary Driscoll was commissioned in 2007 as an Armor Officer through the U.S. Army Officer Candidate School. While on active duty, he led a cavalry platoon in the 10th Mountain Division at Fort Drum, New York, and deployed to Baghdad, Iraq, in support of Operation Iraqi Freedom in 2009. His military awards include the Army Commendation Medal, Ranger Tab, and Combat Action Badge. After departing active duty, Secretary Driscoll attended Yale Law School and worked in Yale’s Veterans Legal Services Clinic. He has held leadership roles in investment banking, private equity, and business operations, including as Chief Operating Officer of a $200 million venture capital fund. Secretary Driscoll holds a Bachelor of Science in Business Administration from the University of North Carolina at Chapel Hill and a Juris Doctor from Yale Law School. He is a member of the North Carolina State Bar, the Rotary Club, VFW Post 1134, and Iraq and Afghanistan Veterans of America. A native of Boone, North Carolina, Secretary Driscoll comes from a family with a legacy of military service. His grandfather served in the Army during World War II as a decoder, and his father served during Vietnam as an infantryman. He is married to his high-school sweetheart, and they have two children. Shawn Ryan Show Sponsors: ⁠https://betterhelp.com/srs⁠ This episode is sponsored. Give online therapy a try at betterhelp.com/srs and get on your way to being your best self. ⁠https://bruntworkwear.com⁠ – USE CODE SRS ⁠https://calderalab.com/srs⁠ Use code SRS for 20% off your first order. ⁠https://meetfabric.com/shawn⁠ ⁠https://shawnlikesgold.com⁠ ⁠https://helixsleep.com/srs⁠ ⁠https://www.hulu.com/welcome⁠ ⁠https://ketone.com/srs⁠ Visit https://ketone.com/srs for 30% OFF your subscription order. ⁠https://moinkbox.com/srs⁠ ⁠https://patriotmobile.com/srs⁠ ⁠https://rocketmoney.com/srs⁠ ⁠https://ROKA.com⁠ – USE CODE SRS ⁠https://ziprecruiter.com/srs Dan Driscoll Links: X - https://x.com/SecArmy U.S. Army Bio - https://www.army.mil/leaders/sa/bio Learn more about your ad choices. Visit podcastchoices.com/adchoices
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  • #238 Sriram Krishnan - Senior White House Policy Advisor for AI
    Sriram Krishnan is an entrepreneur, venture capitalist, and former senior product leader at tech giants like Microsoft, Facebook, Twitter (now X), and Snap. Born in Chennai, India, he began his career at Microsoft before moving to Silicon Valley, where he contributed to product development at leading companies and later transitioned to venture capital as a General Partner at Andreessen Horowitz from 2021 to 2024, focusing on consumer and enterprise investments. In December 2024, President-elect Donald Trump appointed him as Senior Policy Advisor for Artificial Intelligence at the White House Office of Science and Technology Policy, tasked with advancing U.S. dominance in AI amid global competition. Krishnan co-hosted "The Aarthi and Sriram Show" podcast with his wife Aarthi Ramamurthy, interviewing tech leaders and exploring innovation topics. A prolific writer and speaker, he advocates for immigration reform to attract global talent, ethical AI development, and bridging technology with policy to foster economic growth. Shawn Ryan Show Sponsors: https://betterhelp.com/srs This episode is sponsored. Give online therapy a try at betterhelp.com/srs and get on your way to being your best self. https://bruntworkwear.com – USE CODE SRS https://calderalab.com/srs Use code SRS for 20% off your first order. https://meetfabric.com/shawn https://shawnlikesgold.com https://helixsleep.com/srs https://www.hulu.com/welcome https://ketone.com/srs Visit https://ketone.com/srs for 30% OFF your subscription order. https://moinkbox.com/srs https://patriotmobile.com/srs https://rocketmoney.com/srs https://ROKA.com – USE CODE SRS https://ziprecruiter.com/srs Sriram Krishnan Links: X personal - https://x.com/sriramk X official - https://x.com/skrishnan47 Website - https://sriramk.com Learn more about your ad choices. Visit podcastchoices.com/adchoices
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  • #237 Steven Rinella - Founder of MeatEater
    Steven Rinella is an American outdoorsman, writer, and television host, best known for promoting ethical hunting, wildlife conservation, and field-to-table cooking. He is the founder of MeatEater, Inc., a company that produces hunting, fishing, and outdoor lifestyle content across multiple platforms, including television, podcasts, and digital media. As the host of "MeatEater", a long-running TV series on Netflix and many other platforms, Rinella takes viewers into the field, blending hunting adventures with education on wildlife, ecology, and sustainable food sourcing. A hallmark of the show is its authenticity—highlighting not just the successes but also the challenges of hunting, including the reality that not every hunt ends in a filled tag. Each episode also emphasizes cooking and consuming wild game, reinforcing the deep connection between hunting and food. In addition to the TV series, Rinella hosts "The MeatEater Podcast", America's most listened-to outdoors podcast, which ranks among the top ten sports podcasts overall. Featuring expert guests, in-depth discussions on conservation, and plenty of entertaining outdoors stories, the podcast has become a go-to resource for hunters, anglers, and outdoor enthusiasts. An accomplished author, Rinella has written ten books (and three audiobooks) on hunting, wild game cooking, and outdoor survival, including American Buffalo: In Search of a Lost Icon; The MeatEater Guide to Wilderness Skills and Survival; The MeatEater Fish and Game Cookbook; and Outdoor Kids in an Inside World: Getting Your Family out of the House and Radically Engaged with Nature. His writing has appeared in many publications, including Wall Street Journal, Outside, The New York Times, Men's Journal, and Glamour. Rinella also appeared in the Ken Burns documentary, The American Buffalo. Shawn Ryan Show Sponsors: ⁠https://americanfinancing.net/srs⁠ NMLS 182334, nmlsconsumeraccess.org. APR for rates in the 5s start at 6.327% for well qualified borrowers. Call 866-781-8900, for details about credit costs and terms. ⁠https://tryarmra.com/srs⁠ ⁠https://aura.com/srs⁠ ⁠https://betterhelp.com/srs⁠ This episode is sponsored. Give online therapy a try at betterhelp.com/srs and get on your way to being your best self. ⁠https://bubsnaturals.com⁠ – USE CODE SHAWN ⁠https://shawnlikesgold.com⁠ ⁠https://mypatriotsupply.com/srs⁠ ⁠https://patriotmobile.com/srs⁠ ⁠https://ROKA.com⁠ – USE CODE SRS ⁠https://shopify.com/srs⁠ ⁠https://trueclassic.com/srs⁠ ⁠https://USCCA.com/srs⁠ Steven Rinella Links: Website - https://www.themeateater.com X - https://x.com/stevenrinella IG - https://www.instagram.com/stevenrinella MeatEater Podcast - https://www.themeateater.com/listen/meateater Books - https://www.penguinrandomhouse.com/authors/84146/steven-rinella Learn more about your ad choices. Visit podcastchoices.com/adchoices
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  • #236 Dr. Diane Hennacy - From 1 in 10,000 to 1 in 30: Why Autism Is Rising Faster Than Ever
    Dr. Diane Hennacy is a Johns Hopkins-trained neuropsychiatrist, author, public speaker, and independent researcher exploring the intersection of science, consciousness, and anomalous phenomena like telepathy and psychic abilities. With over 30 years of clinical experience, she has served on the faculty at Harvard Medical School and participated in think tanks on human consciousness at the Salk Institute. Hennacy’s groundbreaking work bridges rigorous scientific inquiry with mysteries of the mind, including studies on autism, savant syndrome, and potential links to extrasensory perception (ESP). Her bestselling book, The ESP Enigma: The Scientific Case for Psychic Phenomena (2009), presents evidence from neuroscience, quantum physics, and case studies to explain psychic experiences. A student of ancient wisdom traditions and an award-winning clinician, she has spoken at international scientific conferences, the United Nations, and venues like TEDx, advocating for open-minded exploration of human potential and consciousness. Hennacy, who also held the title of Miss Oregon Senior America 2017, continues her research through the Hennacy Institute for Consciousness Research, emphasizing integrative medicine and the evolution of human awareness. Shawn Ryan Show Sponsors: https://americanfinancing.net/srs NMLS 182334, nmlsconsumeraccess.org. APR for rates in the 5s start at 6.327% for well qualified borrowers. Call 866-781-8900, for details about credit costs and terms. https://tryarmra.com/srs https://aura.com/srs https://betterhelp.com/srs This episode is sponsored. Give online therapy a try at betterhelp.com/srs and get on your way to being your best self. https://bubsnaturals.com – USE CODE SHAWN https://shawnlikesgold.com https://mypatriotsupply.com/srs https://patriotmobile.com/srs https://ROKA.com – USE CODE SRS https://shopify.com/srs https://trueclassic.com/srs https://USCCA.com/srs Dr. Diane Hennacy Links: Website - https://drdianehennacy.com X - https://x.com/drhennacy41125 Buy The ESP Enigma - https://drdianehennacy.com/purchase-esp-enigma Learn more about your ad choices. Visit podcastchoices.com/adchoices
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The "Shawn Ryan Show" is hosted by Shawn Ryan, former U.S. Navy SEAL, CIA Contractor, and Founder of Vigilance Elite. We tell REAL stories about REAL people from all walks of life. We discuss the ups and downs, wins and losses, successes and struggles, the good and bad in a respectful but candid way with our guest. We're better than entertainment, we're the REAL thing. Please enjoy the show.
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