BBC RADIO 4 - In our time

Melvyn Bragg and guests discuss the Austrian princess Maria Antonia, child bride of the future French King Louis XVI. Their marriage was an attempt to bring about a major change in the balance of power in Europe and to undermine the influence of Prussia and Great Britain, but she had no say in the matter and was the pawn of her mother, the Empress Maria Theresa. She fulfilled her allotted role of supplying an heir, but was sent to the guillotine in 1793 in the French Revolution, a few months after her husband, following years of attacks on her as a woman who, it was said, betrayed the King and as a foreigner who betrayed France to enemy powers. When not doing these wrongs, she was said to be personally bankrupting France. Her death shocked royal families throughout Europe, and she became a powerful symbol of the consequences of the Revolution. With Catriona Seth Marshal Foch Professor of French Literature at the University of Oxford Katherine Astbury Professor of French Studies at the University of Warwick and David McCallam Reader in French Eighteenth-Century Studies at the University of Sheffield Producer: Simon Tillotson

Melvyn Bragg and guests discuss the properties of atoms or molecules with a single unpaired electron, which tend to be more reactive, keen to seize an electron to make it a pair. In the atmosphere, they are linked to reactions such as rusting. Free radicals came to prominence in the 1950s with the discovery that radiation poisoning operates through free radicals, as it splits water molecules and produces a very reactive hydroxyl radical which damages DNA and other molecules in the cell. There is also an argument that free radicals are a byproduct of normal respiration and over time they cause an accumulation of damage that is effectively the process of ageing. For all their negative associations, free radicals play an important role in signalling and are also linked with driving cell division, both cancer and normal cell division, even if they tend to become damaging when there are too many of them. With Nick Lane Professor of Evolutionary Biochemistry at University College London Anna Croft Associate Professor at the Department of Chemical and Environmental Engineering at the University of Nottingham And Mike Murphy Professor of Mitochondrial Redox Biology at Cambridge University Producer: Simon Tillotson

Melvyn Bragg and guests discuss Bernard Mandeville (1670-1733) and his critique of the economy as he found it in London, where private vices were condemned without acknowledging their public benefit. In his poem The Grumbling Hive (1705), he presented an allegory in which the economy collapsed once knavish bees turned honest. When republished with a commentary, The Fable of the Bees was seen as a scandalous attack on Christian values and Mandeville was recommended for prosecution for his tendency to corrupt all morals. He kept writing, and his ideas went on to influence David Hume and Adam Smith, as well as Keynes and Hayek. With David Wootton Anniversary Professor of History at the University of York Helen Paul Lecturer in Economics and Economic History at the University of Southampton And John Callanan Senior Lecturer in Philosophy at King’s College London Producer: Simon Tillotson

In the second of two programmes marking In Our Time's 20th anniversary on 15th October, Melvyn Bragg and guests discuss Shakespeare's versions of history, continuing with the Roman plays. Rome was the setting for Titus Andronicus, Julius Caesar, Coriolanus and parts of Antony and Cleopatra and these plays gave Shakespeare the chance to explore ideas too controversial for English histories. How was Shakespeare reimagining Roman history, and what impact has that had on how we see Rome today? The image above is of Marlon Brando playing Mark Antony in a scene from the film version of Shakespeare's Julius Caesar, 1953 With Sir Jonathan Bate Provost of Worcester College, University of Oxford Catherine Steel Professor of Classics and Dean of Research in the College of Arts at the University of Glasgow And Patrick Gray Associate Professor of English Studies at Durham University Producer: Simon Tillotson

In the first of two programmes marking In Our Time's 20th anniversary on 15th October, Melvyn Bragg and guests discuss Shakespeare's versions of history, starting with the English Plantagenets. His eight plays from Richard II to Richard III were written out of order, in the Elizabethan era, and have had a significant impact on the way we see those histories today. In the second programme, Melvyn discusses the Roman plays. The image above is of Richard Burton (1925 - 1984) as Henry V in the Shakespeare play of the same name, from 1951 With Emma Smith Professor of Shakespeare Studies at Hertford College, University of Oxford Gordon McMullan Professor of English at King’s College London and Director of the London Shakespeare Centre And Katherine Lewis Senior Lecturer in Medieval History at the University of Huddersfield Producer: Simon Tillotson