The a16z Show

Sophia Dew and Sofia Puccini are joined by Ruby Thelot, designer, artist, cyberethnographer, professor at NYU, and founder of 13101401, for a wide-ranging conversation about internet culture, AI, digital communities, and how technology is reshaping the way we relate to one another.

Drawing on years of research into online behavior, Ruby explains how digital cultures form, why algorithms shape more than just what we see, and what AI is changing about creativity, communication, and identity. They discuss cyberethnography, online subcultures, "machinic taste," AI companions, social norms, internet language, and why Americans often say they dislike AI—even as they increasingly rely on it in everyday life.

 

Resources:

Follow Ruby X: https://x.com/being_on_line

Substack: https://beingonline.substack.com/

Follow Sophia on X: https://x.com/sophiadew

Follow Sofia on X: https://x.com/schisofrenia

Follow MTS on X: https://x.com/mtslive

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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Marc Andreessen, Chris Dixon, and Robert Hackett discuss one of the most consequential policy debates facing the crypto industry: the push for comprehensive U.S. market structure legislation and what regulatory clarity could mean for innovation, financial markets, and America's technological leadership.

They explore the CLARITY Act, stablecoins, securities law, consumer protection, and why both builders and financial institutions are calling for clear rules of the road. Along the way, they discuss the lessons of the early internet, FTX, open financial networks, and why they believe thoughtful regulation can strengthen innovation rather than slow it down.

 

Resources:

Follow Marc Andreessen on X: https://x.com/pmarca

Follow Chris Dixon on X: https://x.com/cdixon

Follow Robert Hackett on X: https://x.com/rhackett

Follow a16z Crypto on X: https://x.com/a16zcrypto

Why Bitcoin matters: https://a16z.com/why-bitcoin-matters/

What builders need to know about the CLARITY Act: https://a16zcrypto.com/posts/article/clarity-act-what-why-matters

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Follow our host: https://twitter.com/eriktorenberg

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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Sarah Wang and Kimberly Tan are joined by Jesse Zhang and Ashwin Sreenivas, co-founders of Decagon, to discuss the evolution of enterprise AI agents, why the company increasingly relies on open-source models, and how it is helping some of the world’s largest companies deploy AI in production.

Decagon has become one of the fastest-growing AI companies by building agents that automate customer support, sales, and operational workflows. Jesse, Decagon’s CEO, and Ashwin, its president, explain how the company is building enterprise AI at scale.

They unpack why Decagon moved most of its inference to open-source models, how latency, evaluation, and fine-tuning shape production AI systems, and why enterprise AI requires far more than simply plugging into frontier models. The conversation also explores forward-deployed engineering, enterprise sales, AI’s impact on jobs, and why application companies will continue to thrive alongside the foundation model labs.

 

Resources:

Follow Jesse Zhang on X: https://x.com/thejessezhang

Follow Ashwin Sreenivas on X: https://x.com/AshwinSreenivas

Follow Sarah Wang on X: https://x.com/sarahdingwang

Follow Kimberly Tan on X: https://x.com/kimberlywtan

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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Alex Rampell and Olivia Moore speak with Lassie cofounders Steijn Pelle and Frédéric Renken about bringing AI to one of the most overlooked parts of the economy: small businesses.

Inspired by time spent working inside dental practices, Pelle and Renken set out to automate the administrative work that keeps healthcare providers away from patients. They discuss how AI agents are changing billing, insurance claims, patient payments, and other operational workflows, allowing practices to spend less time on paperwork and more time delivering care.

The conversation explores AI agents, software that performs work rather than simply storing information, onboarding AI into real-world businesses, and why healthcare administration offers one of the biggest opportunities for automation. Along the way, they discuss product design, go-to-market strategy, and what it takes to build AI systems that operate reliably in complex business environments.

 

Resources:

Follow Steijn Pelle on X: https://x.com/steijnpelle

Follow Frédéric Renken on X: https://x.com/fredericrenken

Follow Alex Rampell on X: https://x.com/arampell

Follow Olivia Moore on X: https://x.com/omooretweets

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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Justine Moore, partner at Andreessen Horowitz, joins New Economies to explore the rapid evolution of generative media and why AI-native content is reaching an inflection point. They discuss the rise of AI micro-dramas, how creators are building entirely new forms of entertainment, and why the biggest opportunities may lie not in replacing Hollywood—but in expanding who gets to create.

They also cover the future of creator tools, AI agents for individuals, generative video, AI "slop," the economics of AI-native studios, and where founders should be building next as consumer AI enters a new phase.

 

Resources:

Follow Justine Moore on X: https://x.com/venturetwins

Watch the episode on YouTube: https://www.neweconomies.co/p/justine -moore-andreessen-horowitz

Listen to more from New Economies: https://www.neweconomies.co/

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Find a16z on YouTube: YouTube
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Follow our host: https://twitter.com/eriktorenberg

Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

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