Host Jessica Seidelman, MD has an in-depth discussion with Kerry LaPlante, Pharm.D., FCCP, FIDSA, FIDP, and Julie Ann Justo, Pharm.D. in the opening episode of this 3-part series. They discuss why PJI infections are so difficult to treat, and advances in antimicrobial agents in the pipeline. This episode is sponsored by BONESUPPORT™, makers of CERAMENT® G with Gentamicin. CERAMENT G is an FDA-designated breakthrough device offering proven bone remodeling with reliable elution of broad-spectrum Gentamicin. CERAMENT G has a 96% success rate in eradication of infection in a single-stage for patients with fracture related infections and chronic osteomyelitis. To learn more and review CERAMENT G cases, visit their website at BONESUPPORT.com Listen to Breakpoints: The SIDP Podcast References: “Antibiotic Therapy for 6 or 12 Weeks for Prosthetic Joint Infection” PMID 34042388 “NDM-9 resistance to taniborbactam” PMID 36796395 “Wide dissemination of Gram-negative bacteria producing the taniborbactam-resistant NDM-9 variant: a One Health concern” PMID 37394537 IDSA 2024 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections “Dalbavancin for the Treatment of Osteomyelitis in Adult Patients: A Randomized Clinical Trial of Efficacy and Safety” PMID 30648126 “Corynebacterium striatum Prosthetic Joint Infection Successfully Treated with Long-Term Dalbavancin” PMID 36985124 “Emergence of Dalbavancin, Vancomycin, and Daptomycin Nonsusceptible Staphylococcus aureus in a Patient Treated with Dalbavancin: Case Report and Isolate Characterization” PMID 35510938 “Local antibiotic delivery via intra-articular catheter infusion for the treatment of periprosthetic joint infection: a systematic review” PMID 38691147 “A High-Affinity Native Human Antibody Disrupts Biofilm from Staphylococcus aureus Bacteria and Potentiates Antibiotic Efficacy in a Mouse Implant Infection Model” PMID 26833157 FOLLOW us on X @jointapproach or Instagram @jointapproachpodcast for more announcements and content, and reach out to us at
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